{"id":"W4386778998","doi":"10.14218/jcth.2023.00095","title":"Comprehensive Bile Acid Profiling of ABCB4-mutated Patients and the Prognostic Role of Taurine-conjugated 3α,6α,7α,12α-Tetrahydroxylated Bile Acid in Cholestasis","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical and Translational Hepatology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; BC Cancer Agency","funders":"","keywords":"Taurine; Cholestasis; Bile acid; Medicine; Gastroenterology; Internal medicine; Ursodeoxycholic acid; Biochemistry; Chemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003018682,0.000255014,0.0003036981,0.000778675,0.000226186,0.0004966313,0.0001572663,0.0003351516,0.001024857],"category_scores_gemma":[0.0007503629,0.0001048944,0.0002472718,0.000593188,0.0001827762,0.0002030733,0.0003127508,0.0002292375,0.0002130622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002527772,"about_ca_system_score_gemma":0.0001812922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001278767,"about_ca_topic_score_gemma":0.001802439,"domain_scores_codex":[0.9998559,0.00003151074,0.00002030842,0.00003553324,0.00002219467,0.00003460563],"domain_scores_gemma":[0.9996603,0.00005024728,0.0001138673,0.00003151199,0.00005333992,0.00009064543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005180074,0.00002239646,0.9872025,0.00001106278,0.00006404725,0.0001309011,0.00003464177,0.0001517049,0.006563528,0.00002756325,0.0001095775,0.00516411],"study_design_scores_gemma":[0.00001536031,0.0002380985,0.9948177,0.000008138297,0.00009288083,0.001109448,0.00008493056,0.001052797,0.00212814,0.00008787836,0.0003591647,0.000005473777],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993774,0.0001975499,0.0000928827,0.00002598346,0.000001667406,0.00000263921,0.0001319709,0.000007745899,0.0001622839],"genre_scores_gemma":[0.9995993,0.00003394571,0.00007727632,0.00001133947,0.000002333031,0.000002068089,0.0001946367,0.000001178853,0.00007796394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001278767,"threshold_uncertainty_score":0.003428519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02641872885976468,"score_gpt":0.3206164522403556,"score_spread":0.2941977233805909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}