{"id":"W4386780081","doi":"10.1016/j.dld.2023.08.042","title":"Real-world effectiveness and safety of ustekinumab in bio-naive patients with moderate-to-severe Crohn's disease: A Canadian multi-center study","year":2023,"lang":"en","type":"article","venue":"Digestive and Liver Disease","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; McMaster University; McGill University; University of Calgary; McGill University Health Centre","funders":"Janssen Canada","keywords":"Ustekinumab; Medicine; Crohn's disease; Adverse effect; Internal medicine; Disease; Surgery; Infliximab","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001093017,0.0002369199,0.000192673,0.0002287092,0.0001128817,0.0000269378,0.00009555252,0.00003989938,0.000006367286],"category_scores_gemma":[0.0000683471,0.0002137466,0.00003877536,0.0002232353,0.000112872,0.00001778904,0.0001360584,0.00006279033,0.000005755163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005886994,"about_ca_system_score_gemma":0.0002989191,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004496956,"about_ca_topic_score_gemma":0.02734537,"domain_scores_codex":[0.9986345,0.0001942653,0.0001654305,0.0005375445,0.0001487817,0.0003194992],"domain_scores_gemma":[0.9986749,0.00002640145,0.00004958655,0.0002636068,0.0001509034,0.0008345825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009319255,0.0005609103,0.9879339,0.0001300146,0.00008240344,0.0009974536,0.0002852089,0.0003013228,0.00001964352,0.00001829563,0.00003705759,0.000314555],"study_design_scores_gemma":[0.005330427,0.0001358289,0.9936687,0.0001324865,0.00007547369,1.857473e-7,0.0001149864,0.0001843488,0.00001161261,0.000005800292,0.00005977971,0.0002803565],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970005,0.00006852437,0.000007549079,0.0000163968,0.00003048545,0.001520111,0.00128776,0.00001240468,0.00005632432],"genre_scores_gemma":[0.9992263,0.00004757174,0.00001011741,0.00006566975,0.00001841912,0.0001438152,0.0003648037,0.00003036156,0.00009288843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02284842,"threshold_uncertainty_score":0.9904031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007420089180703125,"score_gpt":0.2344195970503324,"score_spread":0.2269995078696292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}