{"id":"W4386784049","doi":"10.1158/1557-3265.aacrahns23-po-082","title":"Abstract PO-082: Antigen presentation and inflammatory effects on immune surveillance: Window of opportunity metformin monotherapy trial for squamous cell carcinoma of the head and neck (HNSCC)","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Head and neck squamous-cell carcinoma; Metformin; Oncology; Tumor microenvironment; Internal medicine; Cancer; Cancer research; Head and neck cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005842853,0.0004869937,0.0008861134,0.0001809033,0.0002578867,0.0006677878,0.0003064595,0.0005846067,0.003234578],"category_scores_gemma":[0.0003996045,0.0002153309,0.0006046564,0.000184572,0.0003092165,0.0004904051,0.0002267174,0.001203431,0.0003160594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003368928,"about_ca_system_score_gemma":0.0005551888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003497907,"about_ca_topic_score_gemma":0.001210113,"domain_scores_codex":[0.9998462,0.00006654086,0.00001230921,0.00002942327,0.00001662771,0.000028852],"domain_scores_gemma":[0.9997607,0.00004179818,0.00004982912,0.00001877377,0.0000246999,0.0001043084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9048223,0.01040404,0.006359675,0.0005692737,0.00086701,0.00007892533,0.00006864513,0.000649947,0.04004344,0.000139163,0.0009711728,0.03502626],"study_design_scores_gemma":[0.4371078,0.5089492,0.03837552,0.00006929481,0.00145905,0.0001310589,0.0001205262,0.001693788,0.009536242,0.0002328809,0.002282598,0.00004196943],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979657,0.0006768681,0.00007410565,0.0001238563,0.00003963368,0.0002779404,0.0003078312,0.00001369973,0.0005204629],"genre_scores_gemma":[0.9969171,0.0003971159,0.0004100872,0.0001756587,0.00006835016,0.0005191453,0.0004164662,0.000006230897,0.001089944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003234578,"threshold_uncertainty_score":0.01082069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.191521908110743,"score_gpt":0.489257773891176,"score_spread":0.297735865780433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}