{"id":"W4386784049","doi":"10.1158/1557-3265.aacrahns23-po-082","title":"Abstract PO-082: Antigen presentation and inflammatory effects on immune surveillance: Window of opportunity metformin monotherapy trial for squamous cell carcinoma of the head and neck (HNSCC)","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Head and neck squamous-cell carcinoma; Metformin; Oncology; Tumor microenvironment; Internal medicine; Cancer; Cancer research; Head and neck cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002263024,0.0001252928,0.0005241441,0.0001189927,0.0001041003,0.00001355671,0.0001080984,0.0001287199,0.00003142252],"category_scores_gemma":[0.000762002,0.00008395294,0.0001830985,0.0002607002,0.0002922136,0.00003982569,0.00007633839,0.0003007455,0.000001252064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007494781,"about_ca_system_score_gemma":0.0005229129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001623826,"about_ca_topic_score_gemma":0.0003217389,"domain_scores_codex":[0.9980469,0.0002557792,0.0005991485,0.0003171062,0.0004987075,0.0002824019],"domain_scores_gemma":[0.9951137,0.003894663,0.0001998931,0.0003856474,0.0002313811,0.0001747743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04347992,0.0007073174,0.8734168,0.001316916,0.0001235014,0.00001777297,0.0003008384,0.000008068297,0.003579786,0.00003270654,0.00153807,0.07547835],"study_design_scores_gemma":[0.0474447,0.003723318,0.9042702,0.0001503059,0.00002798605,5.852014e-7,0.0000673779,0.00003482341,0.04359845,0.0001136211,0.0005052906,0.00006337973],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930613,0.002392245,4.344737e-7,0.0009926403,0.0002449569,0.003070603,0.00008455143,0.00001063621,0.0001426391],"genre_scores_gemma":[0.994568,0.004491246,0.00001056269,0.00005061924,0.0002715037,0.0004256424,0.0000198015,0.00002370492,0.0001388478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07541497,"threshold_uncertainty_score":0.3423502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.191521908110743,"score_gpt":0.489257773891176,"score_spread":0.297735865780433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}