{"id":"W4386784057","doi":"10.1158/1557-3265.aacrahns23-pr06","title":"Abstract PR06: Cooperative HPV and YAP-mediated oncogenic reprogramming of oral progenitors into cancer stem cells at single cell resolution","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Cancer research; Carcinogenesis; Progenitor cell; Reprogramming; Stem cell; Ectopic expression; Cancer stem cell; SOX2; Cell cycle; Cell biology; Cell; Cancer; Cell culture; Transcription factor; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626576,0.0001841761,0.000167542,0.0001753974,0.0001316173,0.0003898138,0.0002703175,0.0002770873,0.002197673],"category_scores_gemma":[0.00008315009,0.0001458749,0.0002129941,0.0001153593,0.0001887472,0.0002283577,0.0003323732,0.0005431219,0.0006936894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205623,"about_ca_system_score_gemma":0.0001654736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004015641,"about_ca_topic_score_gemma":0.0005581803,"domain_scores_codex":[0.999877,0.00000940706,0.00001359441,0.00003670989,0.00004021194,0.0000231208],"domain_scores_gemma":[0.9999154,0.0000140198,0.00002306865,0.0000148265,0.00001107753,0.00002157415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002736428,0.00001165063,0.00007663707,0.00001342552,0.000001096448,0.00002072911,0.000009266107,0.00003999221,0.9986976,0.0001280702,0.00003401087,0.0009401056],"study_design_scores_gemma":[0.000006768432,0.0001025482,0.001444951,0.000003013653,0.000003537297,0.0001101719,0.00001840891,0.0009352902,0.9949803,0.00003851466,0.002353985,0.000002528112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812455,0.0006676294,0.01299164,0.00008472702,0.00002877292,0.00007986412,0.0009631142,0.0002456996,0.003693064],"genre_scores_gemma":[0.9733739,0.0005706624,0.01411404,0.00004773452,0.000009134347,0.0000932684,0.00134699,0.00009533261,0.01034881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002197673,"threshold_uncertainty_score":0.007351995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1849371454460142,"score_gpt":0.4691208612884535,"score_spread":0.2841837158424393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}