{"id":"W4386784280","doi":"10.1158/1557-3265.aacrahns23-po-057","title":"Abstract PO-057: Systemic delivery of miR-27a* using ultrasound-targeted microbubble cavitation causes tumor regression","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer research; Microbubbles; In vivo; PI3K/AKT/mTOR pathway; microRNA; Head and neck squamous-cell carcinoma; Medicine; Epidermal growth factor receptor; Small interfering RNA; AKT1; Biology; RNA; Pathology; Radiation therapy; Cancer; Ultrasound; Signal transduction; Gene; Head and neck cancer; Internal medicine; Cell biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021031,0.0002596022,0.0002541033,0.0001585461,0.0001203635,0.0001569434,0.0001945989,0.0003001539,0.001633509],"category_scores_gemma":[0.00005664731,0.00009302317,0.0002467932,0.0001066287,0.0002768256,0.0001338226,0.0001074632,0.000778977,0.0004149572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752689,"about_ca_system_score_gemma":0.0003081717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107915,"about_ca_topic_score_gemma":0.000923628,"domain_scores_codex":[0.9998951,0.000008300016,0.00000638914,0.00002902139,0.00003095061,0.00003017333],"domain_scores_gemma":[0.99994,0.0000116607,0.00001402996,0.000007186636,0.000007196566,0.00001989199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001996649,0.00009121097,0.00003975917,0.00002284325,0.000003303428,0.00002789764,0.000007779187,0.00007646434,0.9982587,0.00008264992,0.0001763242,0.001013436],"study_design_scores_gemma":[0.0000196496,0.0005682943,0.0004621533,0.000001748366,0.000006460252,0.00004310107,0.00000757363,0.0009547151,0.9968353,0.000014773,0.001084271,0.000002062286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877957,0.001113537,0.005351696,0.0002327612,0.0001339928,0.0001073342,0.0007038526,0.0003693642,0.00419181],"genre_scores_gemma":[0.9871638,0.0005452522,0.003559942,0.0001061273,0.00002330814,0.0001326419,0.0008027225,0.0000708929,0.007595275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633509,"threshold_uncertainty_score":0.005464613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1820556437045082,"score_gpt":0.4512908888412515,"score_spread":0.2692352451367432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}