{"id":"W4386784301","doi":"10.1158/1557-3265.aacrahns23-po-078","title":"Abstract PO-078: Tissue-resident memory CD8+ T cells correlate with anti-PD-1 response in head and neck cancer and expand upon cDC1 activation in tumor-draining lymph nodes to overcome PD-1 resistance","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Head and neck squamous-cell carcinoma; Cancer research; Immunotherapy; CD8; Cytotoxic T cell; Adoptive cell transfer; Medicine; Flow cytometry; Lymph node; Antigen; T cell; Cancer; Immunology; Immune system; Biology; Head and neck cancer; In vitro; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001454549,0.0002192177,0.0002738276,0.0001956003,0.0001372414,0.0002859342,0.0001351232,0.0002491273,0.005445374],"category_scores_gemma":[0.0001268808,0.000110771,0.0001262925,0.0001331791,0.000190561,0.0001740692,0.0001232696,0.0008453255,0.0007475658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193675,"about_ca_system_score_gemma":0.0002515717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003178656,"about_ca_topic_score_gemma":0.0004840438,"domain_scores_codex":[0.9998959,0.00001502627,0.000006825342,0.00002487077,0.00002702584,0.00003036216],"domain_scores_gemma":[0.9999146,0.00001386724,0.00001509986,0.000007807727,0.00001334141,0.00003514491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002040488,0.0004824984,0.007306935,0.0001157166,0.00001235711,0.00008240494,0.00003810797,0.0001463935,0.977146,0.00006083587,0.0009240973,0.01164417],"study_design_scores_gemma":[0.0005327765,0.01613541,0.1351847,0.00002538413,0.000101286,0.00145989,0.000147247,0.002210989,0.8365258,0.0001547818,0.007508854,0.00001280343],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960794,0.0004742272,0.0006239546,0.00007745703,0.0000181163,0.00007993309,0.0006971515,0.0001023125,0.001847403],"genre_scores_gemma":[0.9932396,0.0001636888,0.0009059043,0.00006840805,0.0000152164,0.000152954,0.001390619,0.00002252672,0.004040999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005445374,"threshold_uncertainty_score":0.01821655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09185202323616003,"score_gpt":0.4365398006842508,"score_spread":0.3446877774480908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}