{"id":"W4386784341","doi":"10.1158/1557-3265.aacrahns23-po-048","title":"Abstract PO-048: Baseline blood DNA methylation-based immune profiles are associated with survival outcomes in head and neck cancer patients on immune checkpoint therapy","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Oncology; Internal medicine; Head and neck squamous-cell carcinoma; Immunotherapy; Immune system; Hazard ratio; Biomarker; Ipilimumab; DNA methylation; Pembrolizumab; Proportional hazards model; Cancer; Head and neck cancer; Immunology; Confidence interval; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002329568,0.0001407555,0.0001888405,0.00028433,0.0001737945,0.0002970899,0.0001831085,0.0002806655,0.002072124],"category_scores_gemma":[0.0008634639,0.000076652,0.000200272,0.0003500623,0.0001571975,0.0002279835,0.0001827579,0.0004335493,0.0002518765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001798475,"about_ca_system_score_gemma":0.0001608181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009397796,"about_ca_topic_score_gemma":0.000963972,"domain_scores_codex":[0.9998711,0.00003196691,0.00001218883,0.00003670834,0.0000217463,0.00002629684],"domain_scores_gemma":[0.9995157,0.0001218918,0.0001884025,0.00002775591,0.00005340921,0.00009294739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008887562,0.00004969431,0.992538,0.00001055095,0.00003518172,0.00004211674,0.0000253804,0.00008060876,0.00261347,0.00001070112,0.0001530869,0.003552341],"study_design_scores_gemma":[0.00001180522,0.0002212269,0.9986707,0.00000197197,0.00002327285,0.0001159732,0.00004179448,0.0002996805,0.000436691,0.00002205098,0.0001530084,0.000001835735],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991936,0.00008155085,0.00009228822,0.00002404146,0.000002795956,0.000004635436,0.0003529122,0.000004428875,0.0002437507],"genre_scores_gemma":[0.9994766,0.00001345932,0.00005137607,0.00001484843,0.000003774284,0.000005888888,0.0002665934,0.000001416562,0.0001659471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002072124,"threshold_uncertainty_score":0.006931961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1666927213534959,"score_gpt":0.4708051583639999,"score_spread":0.304112437010504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}