{"id":"W4386784398","doi":"10.1158/1557-3265.aacrahns23-po-025","title":"Abstract PO-025: The effect of tissue of origin on oncogenesis in HPV-related malignancies: Comparative analysis of molecular and immune signatures in HPV-positive head and neck cancer and cervical cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Carcinogenesis; CDKN2A; Head and neck cancer; Cervical cancer; Cancer; HPV infection; Medicine; Cancer research; Immune system; Somatic cell; Biology; Oncology; Internal medicine; Gene; Immunology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003013616,0.0001275935,0.0002490292,0.0007563712,0.0001998665,0.0004586131,0.0001722198,0.0001815888,0.002688098],"category_scores_gemma":[0.0004481912,0.00006676585,0.0002353471,0.0006218653,0.0002217244,0.0001947025,0.0003076735,0.0001745502,0.0003558565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001529387,"about_ca_system_score_gemma":0.000173951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005456791,"about_ca_topic_score_gemma":0.0005236035,"domain_scores_codex":[0.9997645,0.00004421424,0.00001787204,0.00006963497,0.00005317968,0.00005065457],"domain_scores_gemma":[0.999733,0.00009541828,0.00005816932,0.00002564005,0.00003405873,0.00005359765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003344468,0.00008514501,0.5775625,0.0002604059,0.0002281079,0.0003452176,0.0001562342,0.0002585016,0.4013062,0.000137129,0.0002131124,0.01610294],"study_design_scores_gemma":[0.000007627048,0.0003036209,0.9749197,0.000007687938,0.00009561933,0.0006906286,0.000143201,0.0005078103,0.02250611,0.00006886695,0.0007460574,0.00000310635],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979392,0.0005578018,0.0003338715,0.00001412121,0.00000272008,0.000008001672,0.0005799998,0.00001042274,0.0005538454],"genre_scores_gemma":[0.9984671,0.0001091272,0.0002393181,0.00001464973,0.000003245697,0.00001037738,0.0008649772,0.000007821881,0.0002832938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002688098,"threshold_uncertainty_score":0.008992612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.112505464728907,"score_gpt":0.5185266317447995,"score_spread":0.4060211670158925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}