{"id":"W4386784459","doi":"10.1158/1557-3265.aacrahns23-po-008","title":"Abstract PO-008: Association of plasma Epstein-Barr virus DNA and clinical response in patients with recurrent and/or metastatic nasopharyngeal cancer treated with pembrolizumab or standard-of-care chemotherapy in KEYNOTE-122","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Internal medicine; Pembrolizumab; Oncology; Gemcitabine; Viral load; Clinical trial; Chemotherapy; Cancer; Immunology; Virus; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008956387,0.0004197633,0.0008340326,0.0001807847,0.0001529985,0.0005071114,0.0005054765,0.0005263125,0.005453584],"category_scores_gemma":[0.00131419,0.0002062676,0.0006521051,0.0002763201,0.0003292462,0.0005635145,0.0002757057,0.000973766,0.0005598878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004302549,"about_ca_system_score_gemma":0.0004324507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002042908,"about_ca_topic_score_gemma":0.0003524289,"domain_scores_codex":[0.9995591,0.000163252,0.00003438334,0.0001465409,0.00004903567,0.00004759799],"domain_scores_gemma":[0.9993157,0.0001572702,0.0001822328,0.0000786247,0.00003915549,0.0002269596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8381675,0.008077164,0.0762843,0.0006940966,0.001203659,0.0001292474,0.0000935095,0.0009586108,0.03128461,0.0001188156,0.001844024,0.04114434],"study_design_scores_gemma":[0.112896,0.4152512,0.453473,0.00007952802,0.001610036,0.0005461975,0.000116641,0.002732434,0.009044284,0.000305104,0.003892593,0.00005300517],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975368,0.0004820311,0.0001173799,0.00005876912,0.00002082656,0.0002064056,0.0007832372,0.00001739858,0.0007771194],"genre_scores_gemma":[0.9979882,0.00009966203,0.0001382424,0.00005167485,0.00002634889,0.0001628699,0.0009594515,0.00000345306,0.0005701522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005453584,"threshold_uncertainty_score":0.01824409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0866717300103274,"score_gpt":0.457640037991458,"score_spread":0.3709683079811306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}