{"id":"W4386784474","doi":"10.1158/1557-3265.aacrahns23-po-005","title":"Abstract PO-005: Phase 1/2 study of Ad/PNP with fludarabine for the treatment of head & neck squamous cell carcinoma (HNSCC)","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Antimetabolite; Prodrug; Gemcitabine; Fludarabine; Cytosine deaminase; Adverse effect; Nucleoside analogue; Internal medicine; Head and neck squamous-cell carcinoma; Head and neck cancer; Toxicity; Chemotherapy; Oncology; Pharmacology; Cancer; Gastroenterology; Nucleoside; Genetic enhancement; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00183212,0.00162421,0.001092265,0.0006073898,0.0005035098,0.001160696,0.001181289,0.001290379,0.003673553],"category_scores_gemma":[0.0004251324,0.0004816577,0.0009111384,0.0002813691,0.001107409,0.0007143142,0.0003355555,0.002909563,0.0009043274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001128017,"about_ca_system_score_gemma":0.002021013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002614165,"about_ca_topic_score_gemma":0.004092079,"domain_scores_codex":[0.9996142,0.0001623193,0.00001604551,0.00006623467,0.00004698148,0.00009409366],"domain_scores_gemma":[0.9996485,0.00004105178,0.00003875016,0.00003109011,0.0000304949,0.0002101341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3048224,0.2642079,0.007630192,0.001059206,0.001050431,0.0008297263,0.0005989021,0.005127124,0.2548956,0.001349771,0.01042509,0.1480035],"study_design_scores_gemma":[0.2529557,0.700938,0.007776102,0.00004765924,0.000319767,0.0004030312,0.0001077894,0.00252265,0.0291112,0.000305539,0.005483754,0.00002874482],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880717,0.0008226398,0.0007998237,0.0004257285,0.000123149,0.005506229,0.001239775,0.000120471,0.002890461],"genre_scores_gemma":[0.9801371,0.0009873956,0.00317083,0.0008425446,0.0001149784,0.004952781,0.003201993,0.00003914661,0.006553255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003673553,"threshold_uncertainty_score":0.01228929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2451879578181095,"score_gpt":0.5326432941716704,"score_spread":0.2874553363535609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}