{"id":"W4386784480","doi":"10.1158/1557-3265.aacrahns23-po-003","title":"Abstract PO-003: Lenvatinib with or without pembrolizumab versus chemotherapy for treatment of recurrent or metastatic head and neck squamous cell carcinoma that progressed on platinum therapy and immunotherapy: Phase 2 LEAP-009","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Pembrolizumab; Medicine; Lenvatinib; Cetuximab; Oncology; Internal medicine; Docetaxel; Head and neck squamous-cell carcinoma; Chemotherapy; Head and neck cancer; Radiation therapy; Immunotherapy; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001526411,0.001193749,0.001786643,0.0004729491,0.000421838,0.001207166,0.00114726,0.001417156,0.01128341],"category_scores_gemma":[0.001082881,0.0004620652,0.00174505,0.0003682591,0.0007523564,0.001106594,0.0004504807,0.004138576,0.001417342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001030863,"about_ca_system_score_gemma":0.001996525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008977139,"about_ca_topic_score_gemma":0.00215374,"domain_scores_codex":[0.9995022,0.0002486243,0.00003108508,0.00007831314,0.00004776151,0.00009193874],"domain_scores_gemma":[0.9993805,0.0001005697,0.0001168838,0.00004559997,0.0000387723,0.0003177314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9187279,0.02286965,0.00107901,0.000601893,0.0007908509,0.00008455971,0.00005982896,0.0008003415,0.009296763,0.0002360482,0.003358066,0.04209503],"study_design_scores_gemma":[0.8301942,0.1611532,0.00377565,0.0000454431,0.0004261524,0.00008084853,0.00002284887,0.0007378757,0.001558207,0.0001966682,0.001793637,0.00001519977],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726208,0.003469891,0.000843568,0.001316216,0.0005049882,0.009816537,0.00391876,0.0002384356,0.00727085],"genre_scores_gemma":[0.9719898,0.001687582,0.002409117,0.001941967,0.0003731304,0.008290597,0.004510637,0.00006086153,0.008736338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01128341,"threshold_uncertainty_score":0.03774685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4360404556269196,"score_gpt":0.5483569098400536,"score_spread":0.112316454213134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}