{"id":"W4386784510","doi":"10.1158/1557-3265.aacrahns23-po-002","title":"Abstract PO-002: Pembrolizumab as neoadjuvant and adjuvant therapy in combination with standard of care in resectable, locally advanced head and neck squamous cell carcinoma: Phase 3 KEYNOTE-689","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Pembrolizumab; Head and neck squamous-cell carcinoma; Adjuvant; Radiation therapy; Neoadjuvant therapy; Internal medicine; Larynx; Oncology; Adjuvant therapy; Stage (stratigraphy); Head and neck cancer; Surgery; Cancer; Immunotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001048918,0.0009371588,0.00124197,0.0004681486,0.0004685551,0.0008965732,0.001121099,0.001230024,0.01247702],"category_scores_gemma":[0.0006326959,0.0004313723,0.0008524672,0.0003308547,0.0006976387,0.0008258428,0.000369769,0.002891291,0.001875255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007607348,"about_ca_system_score_gemma":0.001633661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007560516,"about_ca_topic_score_gemma":0.002321957,"domain_scores_codex":[0.9997063,0.0001283911,0.00001802873,0.00005565858,0.00003609099,0.00005547153],"domain_scores_gemma":[0.9996033,0.00004561406,0.00006803568,0.00003343302,0.00002625642,0.0002233374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7813336,0.06195918,0.002169941,0.0008747212,0.0007493047,0.000138718,0.0001174439,0.001115584,0.04327092,0.0004478971,0.01186276,0.09595995],"study_design_scores_gemma":[0.7505013,0.2372898,0.003888017,0.00004786507,0.0002581195,0.0001075602,0.00002426989,0.0006965607,0.003320947,0.0001963717,0.003652608,0.00001660441],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648457,0.002784733,0.00164019,0.001419657,0.0003828119,0.01376396,0.005139972,0.0004040338,0.009618955],"genre_scores_gemma":[0.9641539,0.001854904,0.004154544,0.001583418,0.0002657287,0.01241158,0.004780119,0.0000762475,0.01071952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01247702,"threshold_uncertainty_score":0.04173976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09353327907684729,"score_gpt":0.4762303452252107,"score_spread":0.3826970661483635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}