{"id":"W4386784570","doi":"10.1158/1557-3265.aacrahns23-po-093","title":"Abstract PO-093: Crenolanib improves PD-1 response and overall survival in immune checkpoint inhibitor resistant murine models of oral squamous cell carcinoma","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Tumor microenvironment; Cancer research; Head and neck squamous-cell carcinoma; Cancer; Immunotherapy; Head and neck cancer; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005535988,0.0002356385,0.0008755136,0.0004083116,0.00008640574,0.0000372366,0.0001880543,0.0002250425,0.0001824086],"category_scores_gemma":[0.000832114,0.0001934747,0.0002385486,0.0005489911,0.0004148216,0.00009874218,0.0003526502,0.0009304916,0.00002521516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004448395,"about_ca_system_score_gemma":0.0009894521,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01701754,"about_ca_topic_score_gemma":0.002336464,"domain_scores_codex":[0.9959134,0.0004611847,0.001226243,0.0007318634,0.0009258522,0.0007414774],"domain_scores_gemma":[0.9962063,0.002263954,0.0001572655,0.0006573623,0.0003395478,0.000375505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1832628,0.007867731,0.4412714,0.003665037,0.0003053357,0.003608479,0.002127568,0.0002091344,0.3252445,0.0002713956,0.008527142,0.02363941],"study_design_scores_gemma":[0.01007293,0.002839219,0.9590172,0.0002694291,0.00004024102,0.000002412169,0.0002540343,0.0003502464,0.02580469,0.0004438595,0.0007300747,0.0001756549],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898942,0.004481374,4.55371e-7,0.003610702,0.0002465899,0.0009223633,0.000130762,0.00003860073,0.0006749787],"genre_scores_gemma":[0.9955128,0.002727909,0.00004729861,0.00005008966,0.0002264099,0.000247962,0.00002927359,0.00005483427,0.00110338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5177458,"threshold_uncertainty_score":0.9895282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1850307409278701,"score_gpt":0.45823194634657,"score_spread":0.2732012054186999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}