{"id":"W4386784622","doi":"10.1158/1557-3265.aacrahns23-po-091","title":"Abstract PO-091: Leveraging tissue-resident CD103+ NK cells for adoptive cell therapy in head and neck cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Head and neck squamous-cell carcinoma; NK-92; Cancer research; Adoptive cell transfer; Granzyme; Perforin; Biology; Granzyme B; Lymphokine-activated killer cell; Population; Immunotherapy; Immunology; Interleukin 21; Cancer; T cell; Medicine; Head and neck cancer; CD8; Immune system","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001541447,0.0002259291,0.000263407,0.0001664739,0.0001307426,0.0004161203,0.0002304206,0.0002631799,0.001553052],"category_scores_gemma":[0.00008240226,0.00006539388,0.0001753736,0.0001276497,0.0001628729,0.0001973413,0.0001830809,0.00084206,0.0004890069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002097606,"about_ca_system_score_gemma":0.0002706393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006910661,"about_ca_topic_score_gemma":0.0009634358,"domain_scores_codex":[0.9998802,0.00001536188,0.00001085224,0.00002738579,0.00003600814,0.00003020005],"domain_scores_gemma":[0.9999522,0.00000726488,0.000009596431,0.000009075032,0.000008752812,0.00001305335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001184631,0.0001788515,0.0003757261,0.00005268712,0.000005597632,0.0000628623,0.00002043783,0.0002022155,0.9890507,0.0001197436,0.0002161845,0.009596479],"study_design_scores_gemma":[0.00004289854,0.0008834171,0.002432081,0.000008332552,0.00002476416,0.0003436313,0.00003247151,0.001633785,0.9897234,0.00004171982,0.004828665,0.000004684518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824598,0.001984823,0.01096631,0.0002206044,0.000104538,0.0002987996,0.0004772691,0.00018966,0.003298223],"genre_scores_gemma":[0.9860559,0.0009134652,0.00812438,0.00009817647,0.0000228324,0.0001494449,0.0004937325,0.00002887222,0.004113344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553052,"threshold_uncertainty_score":0.005195498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2322529119806837,"score_gpt":0.4944557688991713,"score_spread":0.2622028569184877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}