{"id":"W4386784985","doi":"10.1158/1557-3265.aacrahns23-ia04","title":"Abstract IA04: Evaluating the therapeutic potential of ATR inhibitor BAY 1895344 and radiation therapy for head and neck squamous cell carcinoma","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cancer research; Medicine; Head and neck squamous-cell carcinoma; DNA damage; Clonogenic assay; Bay; Cell cycle; Cell; Radiation therapy; Pathology; Biology; Head and neck cancer; Cancer; Internal medicine; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002643306,0.0003129194,0.0004673431,0.0003138258,0.0001627097,0.0003028411,0.0003415422,0.000363382,0.002983254],"category_scores_gemma":[0.0001199119,0.0001513236,0.0003922886,0.0002645588,0.0001935366,0.0002537112,0.0001337802,0.0007111473,0.0003822863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003208805,"about_ca_system_score_gemma":0.0005949807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001693062,"about_ca_topic_score_gemma":0.002921243,"domain_scores_codex":[0.9999113,0.00002292786,0.00000837042,0.0000126289,0.00001811969,0.00002661022],"domain_scores_gemma":[0.9999239,0.00001205079,0.00001508332,0.000008604296,0.00001076723,0.00002948252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01979474,0.01410071,0.00296262,0.0005886479,0.0002016171,0.0001888286,0.00008007241,0.001538423,0.9059957,0.0002545181,0.001152033,0.05314205],"study_design_scores_gemma":[0.004447384,0.2654156,0.03053636,0.00004847622,0.0006696251,0.0005500732,0.0001456143,0.003499977,0.6869902,0.00009926962,0.007568893,0.00002834218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958103,0.002099886,0.0002706884,0.00009750065,0.00004725609,0.0002113003,0.00033165,0.00004027248,0.001091133],"genre_scores_gemma":[0.9946805,0.001732316,0.0006866361,0.00007148607,0.00002360388,0.0001351253,0.0006598763,0.000007947587,0.002002534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002983254,"threshold_uncertainty_score":0.009979963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1520703271832212,"score_gpt":0.4795662263999439,"score_spread":0.3274958992167226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}