{"id":"W4386793970","doi":"10.1016/j.isci.2023.107960","title":"Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"National Institute on Aging; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Fondation Jean-Louis Lévesque; Fondation de la recherche en santé du Nouveau-Brunswick; Glenn Foundation for Medical Research; Fondation pour la Recherche Médicale; Howard Hughes Medical Institute","keywords":"Proteostasis; Caenorhabditis elegans; Chemistry; Lipid droplet; Cell biology; Nanotechnology; Biophysics; Biology; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007570236,0.0003261499,0.0001558801,0.0002961352,0.000195527,0.0001907362,0.0001485395,0.0002013934,0.0005695786],"category_scores_gemma":[0.00006705879,0.0001374817,0.0001440961,0.00009741054,0.0002104245,0.0001802604,0.0002197593,0.0002895567,0.0001047182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004865948,"about_ca_system_score_gemma":0.0002409636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001541289,"about_ca_topic_score_gemma":0.003179357,"domain_scores_codex":[0.9999455,0.000004200819,0.000005552489,0.00001638987,0.00001395917,0.00001428823],"domain_scores_gemma":[0.9999236,0.000006922935,0.00002946356,0.00000470626,0.00001013898,0.00002522538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004299703,0.000005849745,0.000167545,0.00001231228,0.000001550013,0.00001920459,0.000005302276,0.00003542551,0.9993555,0.00002800003,0.00001255385,0.0003137791],"study_design_scores_gemma":[0.00001407997,0.0001333701,0.01735044,0.000008277771,0.00001991674,0.00009671426,0.00003812011,0.0016547,0.9796468,0.00008479533,0.0009419022,0.00001073352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982154,0.0003874347,0.0006302877,0.00003694732,0.000009645254,0.000008913011,0.0002666641,0.00004334575,0.0004012604],"genre_scores_gemma":[0.9968907,0.0003520273,0.001170215,0.00003030435,0.000002517237,0.00001947707,0.00020533,0.00001858954,0.001310811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001541289,"threshold_uncertainty_score":0.003530502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009721983306391124,"score_gpt":0.2411714012321597,"score_spread":0.2314494179257686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}