{"id":"W4386800574","doi":"10.1093/neuonc/noad147.025","title":"INDIGO: A GLOBAL, RANDOMIZED, DOUBLE-BLINDED, PHASE 3 STUDY OF VORASIDENIB VERSUS PLACEBO IN PATIENTS WITH RESIDUAL OR RECURRENT GRADE 2 GLIOMA WITH AN IDH1/2 MUTATION","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Medicine; Placebo; Internal medicine; Adverse effect; Glioma; Gastroenterology; Randomization; Clinical endpoint; Randomized controlled trial; Hazard ratio; Surgery; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001880683,0.001938848,0.002663484,0.0007758152,0.0004816267,0.00138753,0.001077538,0.001848512,0.006604566],"category_scores_gemma":[0.001137485,0.0007351944,0.001651711,0.0005843084,0.001374594,0.001062084,0.0004646197,0.002926341,0.001101771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000825569,"about_ca_system_score_gemma":0.001564524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008744593,"about_ca_topic_score_gemma":0.002881353,"domain_scores_codex":[0.9994418,0.0003461772,0.00002097064,0.00007075709,0.00003420183,0.00008610345],"domain_scores_gemma":[0.9994845,0.000116297,0.0001293727,0.00003249062,0.00003143524,0.0002058197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.970959,0.009116044,0.0005999863,0.0005653316,0.000545992,0.00004649258,0.00006115817,0.0003304559,0.004830937,0.0001369909,0.001198615,0.01160902],"study_design_scores_gemma":[0.9338509,0.06296802,0.001470197,0.00002656742,0.0002511687,0.00003390105,0.00002298469,0.0003074021,0.0003797885,0.0001217196,0.0005533887,0.00001395606],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773802,0.005426759,0.0009397091,0.001252305,0.000578683,0.007405496,0.002095479,0.0004153291,0.004506059],"genre_scores_gemma":[0.9789007,0.002719103,0.001973563,0.002351449,0.0003629074,0.007543236,0.001620608,0.00005521412,0.004473189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006604566,"threshold_uncertainty_score":0.02209443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05769104179859719,"score_gpt":0.3784737549682509,"score_spread":0.3207827131696537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}