{"id":"W4386813039","doi":"10.1016/j.crtox.2023.100126","title":"Methylmercury (MeHg) transcriptionally regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) in Hepa-1c1c7 cells","year":2023,"lang":"en","type":"article","venue":"Current Research in Toxicology","topic":"Mercury impact and mitigation studies","field":"Environmental Science","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Aryl hydrocarbon receptor; NAD+ kinase; Chemistry; Sulforaphane; Transcription factor; Regulation of gene expression; Gene expression; Aryl hydrocarbon receptor nuclear translocator; Cell biology; Biochemistry; Nuclear receptor; KEAP1; Inducer; Gene; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.003212388,0.000211881,0.0003411282,0.0007255112,0.0001914052,0.00003360575,0.0004667715,0.0001507781,0.003642165],"category_scores_gemma":[0.0002670271,0.0002014565,0.00007935601,0.002556506,0.0009339894,0.0002682552,0.0003892996,0.0007921311,0.002064335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004949621,"about_ca_system_score_gemma":0.00009700799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003189831,"about_ca_topic_score_gemma":0.001158935,"domain_scores_codex":[0.9960078,0.0008603833,0.0005054317,0.0006165756,0.0007992039,0.001210634],"domain_scores_gemma":[0.9987608,0.0005732205,0.0000548162,0.0003248445,0.00003344661,0.0002529171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001679374,0.0009238831,0.05396319,0.0001554248,0.00002768195,0.0002153263,0.004637805,0.001225939,0.737975,0.00118312,0.1279113,0.0716134],"study_design_scores_gemma":[0.003238695,0.0006572039,0.6722948,0.0002130119,0.0000160451,0.00002728227,0.002904209,0.00174152,0.0821403,0.02384645,0.2119767,0.0009437971],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99128,0.001135881,0.000008699156,0.002995895,0.000713827,0.00062901,0.00003605339,0.0000604494,0.003140229],"genre_scores_gemma":[0.9958515,0.002279443,0.0001131616,0.00007576452,0.00009718072,0.000278926,0.00005619961,0.00002158243,0.001226207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6558347,"threshold_uncertainty_score":0.9987127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1583107335766868,"score_gpt":0.4257612431480734,"score_spread":0.2674505095713866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}