{"id":"W4386814459","doi":"10.3390/cells12182296","title":"Necroptosis in Organ Transplantation: Mechanisms and Potential Therapeutic Targets","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"University of Toronto","keywords":"Necroptosis; Medicine; Transplantation; Organ transplantation; Organ dysfunction; Organ donation; Reperfusion injury; Solid organ; Ischemia; Heart transplantation; Immunology; Programmed cell death; Internal medicine; Biology; Apoptosis; Sepsis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535954,0.0002912939,0.001014887,0.0002860956,0.00004223437,0.00002532734,0.00008778911,0.0002966699,0.0002591005],"category_scores_gemma":[0.000002247239,0.0002306274,0.0001945802,0.0003106761,0.00003128942,0.00003525003,0.00001203274,0.0002920032,0.0001334897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004102498,"about_ca_system_score_gemma":0.0001001948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001236881,"about_ca_topic_score_gemma":0.000005957692,"domain_scores_codex":[0.9987375,0.00005981082,0.0004492505,0.0003297114,0.0001741152,0.0002496085],"domain_scores_gemma":[0.9995387,0.00006957631,0.0001020407,0.0001780948,0.00001973523,0.00009184841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006272586,0.0001360774,0.00002278439,0.2071741,0.0004002186,0.001862093,0.0007880002,6.147286e-7,0.0006135544,0.0009331118,0.0003021208,0.7877046],"study_design_scores_gemma":[0.004913113,0.0007880707,0.0006584235,0.05267935,0.01688247,0.001703419,0.0002457795,0.00003111856,0.01357727,0.002445936,0.9036287,0.00244632],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001605879,0.9949098,0.003297396,0.0000847405,0.0002515675,0.001011201,0.00008638435,0.0002056977,0.0001371718],"genre_scores_gemma":[0.00009418355,0.997084,0.001167127,0.0001535334,0.00006279587,0.00004316167,0.0002940944,0.00008965297,0.001011511],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9033266,"threshold_uncertainty_score":0.9404714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03406640493724877,"score_gpt":0.3201143598793477,"score_spread":0.2860479549420989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}