{"id":"W4386835218","doi":"10.20944/preprints202306.0984.v2","title":"Suspension-Induced Stem Cell Transition: A Non-Transgenic Method to Generate Adult Stem Cells from Mouse and Human Somatic Cells","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Children's Hospital of Eastern Ontario; Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; Academia Sinica; J.P. Bickell Foundation; University of Ottawa; CHEO Research Institute; Ottawa Hospital Research Institute","keywords":"Stem cell; Cell biology; Somatic cell; Extracellular matrix; Biology; Adult stem cell; Genetically modified mouse; Cell culture; Mesenchymal stem cell; Anoikis; Fibroblast; Cellular differentiation; Cell type; Stromal cell; Embryonic stem cell; Transgene; Cell; Molecular biology; Genetics; Gene; Cancer research; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00059358,0.0004456395,0.0003391881,0.0008854821,0.0003510935,0.0005346047,0.0005112065,0.0004726059,0.002495778],"category_scores_gemma":[0.0002529851,0.0002118765,0.0005834945,0.0004081098,0.0003926537,0.0003107835,0.0005832076,0.00100713,0.002381961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002003486,"about_ca_system_score_gemma":0.0003877551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002395742,"about_ca_topic_score_gemma":0.0004693669,"domain_scores_codex":[0.9996506,0.00004889138,0.00003315445,0.00007425789,0.0001664805,0.00002663222],"domain_scores_gemma":[0.9998159,0.00004338909,0.00003424584,0.00004589716,0.00002962626,0.00003100228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004632811,0.00005110083,0.000208916,0.0000844085,0.000009419633,0.0001169903,0.00004788436,0.00007253881,0.9873411,0.0007438912,0.0004948276,0.01078259],"study_design_scores_gemma":[0.0000230915,0.0003213166,0.001486622,0.00001477777,0.00003248118,0.001114483,0.00002690315,0.001173608,0.9664795,0.0003676199,0.02894356,0.00001602745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2690188,0.00546252,0.6994478,0.0008592931,0.0009411244,0.001361619,0.003490383,0.005835761,0.01358277],"genre_scores_gemma":[0.5747466,0.005861226,0.3804233,0.0006711651,0.0002984697,0.00145892,0.00941925,0.0009871817,0.02613387],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002495778,"threshold_uncertainty_score":0.00834918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1396575133184457,"score_gpt":0.3571733982867035,"score_spread":0.2175158849682578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}