{"id":"W4386836929","doi":"10.3389/fimmu.2023.1260627","title":"Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hamilton Health Sciences Foundation; AstraZeneca","keywords":"Staphylococcus aureus; Hemolysin; Microbiology; Shock (circulatory); Septic shock; Medicine; Alpha (finance); Monoclonal antibody; Circulatory system; Hyperdynamic circulation; Antibody; Immunology; Biology; Sepsis; Bacteria; Vascular resistance; Hemodynamics; Virulence; Anesthesia; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004666214,0.0007941928,0.0008368185,0.0003986389,0.0002328535,0.0003941643,0.0004650131,0.0004721741,0.0007893807],"category_scores_gemma":[0.0003920156,0.0002959616,0.0003981827,0.0001786054,0.0006067514,0.0004736493,0.0002543268,0.001154161,0.0003178656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003107506,"about_ca_system_score_gemma":0.0003887502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004406382,"about_ca_topic_score_gemma":0.0005239175,"domain_scores_codex":[0.9995984,0.00006964505,0.00006239037,0.00007140782,0.00006265953,0.0001353982],"domain_scores_gemma":[0.9995117,0.00004798637,0.0001523971,0.00008757225,0.00004848783,0.0001518136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002887795,0.0009070516,0.0003982644,0.0000368765,0.00002242108,0.0000663651,0.00004757142,0.000122331,0.9927644,0.00009776096,0.00005889836,0.002590263],"study_design_scores_gemma":[0.0007612075,0.03554634,0.005518959,0.00002108451,0.00008873451,0.0006236667,0.00007634066,0.002046332,0.9538318,0.0001063762,0.001360502,0.00001861763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974394,0.0004276932,0.001499155,0.00008500306,0.00005057312,0.0000800043,0.00006238387,0.00005440346,0.0003014687],"genre_scores_gemma":[0.9965751,0.0004137813,0.001617723,0.00008313182,0.00003636782,0.0001359837,0.0001698322,0.00001367646,0.0009544372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008368185,"threshold_uncertainty_score":0.002640724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04363890457146982,"score_gpt":0.2868923610153084,"score_spread":0.2432534564438385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}