{"id":"W4386851661","doi":"10.1016/j.isci.2023.107968","title":"Schlafen-5 inhibits LINE-1 retrotransposition","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"China Scholarship Council; Chinese Academy of Medical Sciences Initiative for Innovative Medicine; National Natural Science Foundation of China","keywords":"Retrotransposon; Ribonucleoprotein; Biology; RNA Helicase A; Cell biology; RNA; Helicase; RNA interference; Genetics; Cell culture; Transposable element; Genome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320234,0.00005089512,0.00004610883,0.000010365,0.0002523678,0.00004216264,0.0001571356,0.00003237739,0.0001869296],"category_scores_gemma":[0.0000263309,0.00001880325,0.00003275936,0.00107723,0.00004713121,0.00009535545,0.00003304625,0.00004235914,0.0006055575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007323285,"about_ca_system_score_gemma":0.000006196542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004075603,"about_ca_topic_score_gemma":0.0002095908,"domain_scores_codex":[0.999382,0.00001534796,0.00008598874,0.0001873402,0.000146655,0.0001826579],"domain_scores_gemma":[0.9998109,0.00004598811,0.00002028476,0.00003272542,0.00003114574,0.00005889246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000001784288,0.00001524052,0.001231562,0.000001024341,6.993055e-7,0.00000229162,0.00006944653,0.00006783957,0.9555641,0.0008998811,0.0002195944,0.0419265],"study_design_scores_gemma":[0.0001542485,0.0003542085,0.7719185,0.00003689115,0.000007417325,0.00001533768,0.0001755615,0.003378211,0.1830196,0.008881386,0.03174643,0.0003122223],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993482,0.00002894259,0.0000144394,0.003751436,0.0001328833,0.00007260362,0.00002489613,0.0001506393,0.002342139],"genre_scores_gemma":[0.998992,0.00002880764,0.00007143589,0.0001522284,0.0001476373,0.000008819236,0.0000304027,2.394996e-7,0.0005683926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7725446,"threshold_uncertainty_score":0.7783418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02823940030298048,"score_gpt":0.2373145124427442,"score_spread":0.2090751121397637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}