{"id":"W4386858237","doi":"10.1021/acs.analchem.3c02574","title":"Development of a DNAzyme Walker for the Detection of APE1 in Living Cancer Cells","year":2023,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Deoxyribozyme; Chemistry; HeLa; Cancer cell; Cancer; Cell; Nanotechnology; Cell biology; Molecular biology; Biochemistry; DNA; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004376322,0.0004940053,0.0003846731,0.0003030046,0.0001790464,0.0002988404,0.0005358272,0.0008595794,0.0009682051],"category_scores_gemma":[0.0004150547,0.00034213,0.0002219869,0.0002247024,0.0003062878,0.0004742038,0.0003196476,0.0007077037,0.0006462526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549894,"about_ca_system_score_gemma":0.0002852559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002059182,"about_ca_topic_score_gemma":0.0003831756,"domain_scores_codex":[0.9997897,0.00003625413,0.0000132224,0.00008097546,0.00006313645,0.0000167266],"domain_scores_gemma":[0.9998011,0.0000558276,0.00003522336,0.00002341982,0.00004236901,0.00004210096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006485823,0.000004452334,0.00003300971,0.00001381373,0.000001131581,0.00001303945,0.000006446394,0.00002918522,0.9989768,0.00007988818,0.00001475865,0.0008210327],"study_design_scores_gemma":[0.000003023647,0.00006921327,0.0001680764,0.000001661827,0.000002123277,0.0001000723,0.000005248429,0.0009484311,0.9977725,0.00002945592,0.00089601,0.000004210874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.677023,0.001552505,0.3163447,0.0004849449,0.0001234325,0.0003665117,0.0003962656,0.001300257,0.002408379],"genre_scores_gemma":[0.6112125,0.00127243,0.3788079,0.0001955158,0.00002426093,0.0004613444,0.0007220968,0.0001250536,0.007178891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009682051,"threshold_uncertainty_score":0.003239036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01569065478574119,"score_gpt":0.2967967895055111,"score_spread":0.28110613471977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}