{"id":"W4386858237","doi":"10.1021/acs.analchem.3c02574","title":"Development of a DNAzyme Walker for the Detection of APE1 in Living Cancer Cells","year":2023,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Deoxyribozyme; Chemistry; HeLa; Cancer cell; Cancer; Cell; Nanotechnology; Cell biology; Molecular biology; Biochemistry; DNA; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002044984,0.00007852828,0.0001304348,0.00002200884,0.00002934379,0.000003043332,0.00009777983,0.0001066352,0.000003081995],"category_scores_gemma":[0.0001144921,0.00005770659,0.00009106059,0.0002131248,0.00006836493,0.000001183051,0.0000595723,0.00005390854,3.33e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001518382,"about_ca_system_score_gemma":0.00004676038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000104698,"about_ca_topic_score_gemma":0.00004150198,"domain_scores_codex":[0.9993597,0.00000659402,0.0002389822,0.0001707957,0.00008668809,0.0001372513],"domain_scores_gemma":[0.9996039,0.0000637357,0.00007780309,0.0001636152,0.00006873666,0.00002215959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002054201,0.00002368771,0.0001759666,0.00005991028,0.00005021229,2.223201e-7,0.00002258905,0.00003090367,0.9911565,0.000001141603,0.00007130512,0.008387084],"study_design_scores_gemma":[0.00007441417,0.00001343276,0.0004944028,0.00003772754,0.00003020864,3.95637e-7,0.0001216809,0.002178567,0.9942169,0.0000112807,0.002748494,0.00007253143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954385,0.0001321436,0.00412874,0.00005316521,0.00001678512,0.00007755768,0.000009873,0.00001234705,0.0001309502],"genre_scores_gemma":[0.9983411,0.0001239678,0.000895298,0.00001739781,0.00004799335,0.00001732404,0.00001190333,0.000007889577,0.0005371444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008314553,"threshold_uncertainty_score":0.2353206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01569065478574119,"score_gpt":0.2967967895055111,"score_spread":0.28110613471977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}