{"id":"W4386861913","doi":"10.1038/s41416-023-02429-1","title":"Hopes, concerns, satisfaction and regret in a precision medicine trial for childhood cancer: a mixed-methods study of parent and patient perspectives","year":2023,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Nursing Research; National Human Genome Research Institute; Cancer Institute NSW; National Health and Medical Research Council; McGill University; Foundation for the National Institutes of Health","keywords":"Regret; Medicine; Clinical trial; Family medicine; Receipt; Precision medicine; Qualitative property; Qualitative research; Randomized controlled trial; Childhood cancer; Clinical psychology; Psychology; Cancer; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.003888301,0.00009836768,0.0006390435,0.0002117917,0.00006014399,0.00002034097,0.00006445705,0.0001299141,0.00005276656],"category_scores_gemma":[0.01014971,0.00008518931,0.0000615963,0.0002900928,0.0002076812,0.00008333538,0.00007247448,0.0008253937,5.584988e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001784898,"about_ca_system_score_gemma":0.0004429138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006484675,"about_ca_topic_score_gemma":0.01645515,"domain_scores_codex":[0.9975329,0.0003408223,0.0008792599,0.0002585725,0.0008051073,0.0001833288],"domain_scores_gemma":[0.9952441,0.003296979,0.0004339159,0.0001059002,0.0007594198,0.0001597078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0121577,0.0003617729,0.04394874,0.0001694772,0.0001842208,0.00007474575,0.008495069,0.00001945848,0.0001579839,0.00002315502,0.001610194,0.9327975],"study_design_scores_gemma":[0.07284223,0.01166765,0.8838556,0.005350643,0.0001686911,0.0001084216,0.02283105,0.0000715691,0.00009918336,0.002024789,0.0008827443,0.00009745779],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553478,0.04030077,0.00003558241,0.002535434,0.0004844143,0.001239342,0.00003345387,0.000005778194,0.00001739253],"genre_scores_gemma":[0.9033504,0.09543854,0.0005464056,0.00006426006,0.0004422016,0.0001044369,9.533815e-7,0.00001683806,0.00003602321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9327,"threshold_uncertainty_score":0.9981882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2207053987811039,"score_gpt":0.5879041545990111,"score_spread":0.3671987558179072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}