{"id":"W4386863242","doi":"10.1101/2023.09.15.557847","title":"The clinical, genomic, and transcriptomic landscape of BRAF mutant cancers","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; EMD Serono; Fondation de l'Hôpital général juif; Jewish General Hospital; Advanced Accelerator Applications; Canadian Institutes of Health Research; Genome Canada; AstraZeneca Canada; AstraZeneca; American Society of Clinical Oncology; Pfizer; Conquer Cancer Foundation","keywords":"Wnt signaling pathway; Transcriptome; Cancer; Melanoma; Cancer research; Biology; Mutant; Mutation; Medicine; Gene; Genetics; Oncology; Internal medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497626,0.0001022487,0.0001726387,0.0007056849,0.0001538451,0.0004075232,0.0001063938,0.0001611619,0.001464013],"category_scores_gemma":[0.0004840571,0.0000750409,0.00013745,0.0007795614,0.0001314332,0.0001341405,0.0001856662,0.0001210382,0.0002236161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645475,"about_ca_system_score_gemma":0.0001122278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001052522,"about_ca_topic_score_gemma":0.001686335,"domain_scores_codex":[0.9998485,0.00002572725,0.00001355918,0.00005144869,0.00002506448,0.00003565259],"domain_scores_gemma":[0.9998158,0.00004279436,0.00007224142,0.000009606182,0.00002602356,0.00003361332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005847289,0.00002112986,0.9606598,0.00005138687,0.00006991734,0.0003789085,0.00007940198,0.0001269931,0.02708667,0.00006658808,0.0005824015,0.01029202],"study_design_scores_gemma":[0.000002835218,0.00004505866,0.9974914,0.000004188364,0.00001714525,0.0007731149,0.00009634512,0.0001531802,0.0008174272,0.00005981098,0.000537386,0.000002273277],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966884,0.0006825114,0.0001516885,0.00005540764,0.000003186808,0.000004396869,0.001999642,0.000009224123,0.0004055665],"genre_scores_gemma":[0.9980323,0.0002151668,0.0001586592,0.00003036114,0.000006159904,0.000006734279,0.001376227,0.000003744496,0.0001706327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001464013,"threshold_uncertainty_score":0.004897594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02277451477685394,"score_gpt":0.2492571770316659,"score_spread":0.2264826622548119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}