{"id":"W4386866042","doi":"10.1016/j.jbc.2023.105266","title":"Hydrophobic moment drives penetration of bacterial membranes by transmembrane peptides","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Cystic Fibrosis Canada","keywords":"Efflux; Transmembrane domain; Antimicrobial peptides; Membrane; Peptide; Transmembrane protein; Biochemistry; Membrane protein; Chemistry; Lipid bilayer; Membrane transport protein; Biophysics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304926,0.0001795311,0.0001195122,0.00004435216,0.0001192516,0.0002242301,0.0001204028,0.0001962373,0.0005627407],"category_scores_gemma":[0.0001481197,0.00007980258,0.0000855485,0.00004535105,0.0002545461,0.0002569246,0.0002579098,0.000370094,0.0001948115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001338257,"about_ca_system_score_gemma":0.0001043273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001366023,"about_ca_topic_score_gemma":0.0001531106,"domain_scores_codex":[0.9999315,0.00001510725,0.000003844583,0.0000117368,0.00001953819,0.00001836322],"domain_scores_gemma":[0.9999012,0.00003418389,0.00002718887,0.000006148065,0.00001020548,0.00002110001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000243593,0.0000084418,0.00006559679,0.00001561219,8.703432e-7,0.00002471901,0.00001213481,0.00006909372,0.9991792,0.0001146848,0.00001924759,0.0004660536],"study_design_scores_gemma":[0.000008701501,0.0001226837,0.000678941,0.000003306553,0.000002163312,0.00009514857,0.0000239498,0.001434336,0.9966704,0.00006039388,0.0008961704,0.000003781186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963328,0.0003334876,0.002143557,0.00008811172,0.00001424319,0.00001099011,0.00002822743,0.00001985212,0.001028759],"genre_scores_gemma":[0.9984193,0.0002122584,0.0008521341,0.00003664567,0.000004950852,0.000006804936,0.00002130644,0.000005365618,0.00044107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005627407,"threshold_uncertainty_score":0.001882493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308018414527267,"score_gpt":0.2472283054175847,"score_spread":0.234148121272312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}