{"id":"W4386870953","doi":"10.1515/chem-2023-0125","title":"Antidiabetic, antioxidant and cytotoxicity activities of <i>ortho</i>- and <i>para</i>-substituted Schiff bases derived from metformin hydrochloride: Validation by molecular docking and <i>in silico</i> ADME studies","year":2023,"lang":"en","type":"article","venue":"Open Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"King Saud University","keywords":"Antioxidant; ADME; Chemistry; Pharmacology; In vivo; Cytotoxicity; Docking (animal); In vitro; Biochemistry; Stereochemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225708,0.0003595642,0.0002397973,0.0002015521,0.00009016648,0.0001581048,0.0002426117,0.0002225946,0.0008182591],"category_scores_gemma":[0.0001771534,0.0001139677,0.0002822202,0.0001666437,0.00009785294,0.0001442956,0.0001189667,0.0003057285,0.0001545909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001458752,"about_ca_system_score_gemma":0.0001284792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004455005,"about_ca_topic_score_gemma":0.0008043131,"domain_scores_codex":[0.9999298,0.00001640903,0.000006163993,0.000011187,0.0000259127,0.00001048963],"domain_scores_gemma":[0.9999361,0.00000799025,0.0000236558,0.000005217624,0.0000146684,0.00001246309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007799305,0.0002226462,0.0008972062,0.0002734586,0.00006415823,0.00009060921,0.00002227029,0.003820191,0.9834386,0.0002630834,0.0001639801,0.009963821],"study_design_scores_gemma":[0.00009233436,0.003359477,0.001984249,0.00001545352,0.00008534567,0.0001001326,0.00002162441,0.009915086,0.9823143,0.00005209166,0.002039019,0.00002074916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943178,0.00182536,0.00235236,0.00004482006,0.00003214605,0.00003301113,0.0002371241,0.00003530005,0.00112214],"genre_scores_gemma":[0.993084,0.001481798,0.004102781,0.0000408432,0.000009056909,0.00002904844,0.0003818962,0.000007502737,0.0008629856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008182591,"threshold_uncertainty_score":0.002737343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03416173078424209,"score_gpt":0.2874371732810512,"score_spread":0.2532754424968091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}