{"id":"W4386880924","doi":"10.21203/rs.3.rs-3311459/v1","title":"Caloric restriction promotes beta cell longevity and delays aging and senescence signatures.","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Diabetes Canada; University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Vanderbilt University","keywords":"Longevity; Caloric theory; Senescence; Cellular senescence; Healthy aging; Biology; Gerontology; Cell biology; Medicine; Endocrinology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003120985,0.0004035004,0.0004594392,0.0004477552,0.0001475696,0.0007968188,0.0001840646,0.0004416737,0.006761],"category_scores_gemma":[0.0005180346,0.0002063042,0.0002676417,0.0003013188,0.0002748393,0.0003627901,0.0004142887,0.0009014721,0.001458915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002354261,"about_ca_system_score_gemma":0.0002922821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005811947,"about_ca_topic_score_gemma":0.0005371476,"domain_scores_codex":[0.9998952,0.00001984155,0.000005113327,0.00002886632,0.0000270233,0.00002385046],"domain_scores_gemma":[0.9997917,0.00003910579,0.00004755964,0.00003627053,0.00002783792,0.00005749615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007968836,0.000288161,0.003094563,0.0003081744,0.00009973731,0.0003467604,0.00007668266,0.0003258853,0.9393244,0.001942906,0.004605609,0.04161829],"study_design_scores_gemma":[0.0007742071,0.002432442,0.1956533,0.0002029334,0.0004115933,0.002086497,0.0003730815,0.003828632,0.737762,0.01191536,0.04449282,0.00006719961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9496365,0.01945226,0.009963052,0.002327123,0.0009843912,0.00003296643,0.004232034,0.0007290898,0.01264259],"genre_scores_gemma":[0.9648408,0.007727474,0.003847329,0.0003954801,0.000239228,0.00006012478,0.002623523,0.00024132,0.02002474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006761,"threshold_uncertainty_score":0.02261782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08193040882737572,"score_gpt":0.3714294454237271,"score_spread":0.2894990365963514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}