{"id":"W4386881796","doi":"10.1182/bloodadvances.2022008899","title":"CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216","year":2023,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Institute for Research in Immunology and Cancer; McGill University; Centre hospitalier universitaire de Québec; Université Laval; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; CHU Sainte-Justine Foundation; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; Child Health Research Foundation; Merck Canada; Cancer Research Society; Fondation Charles-Bruneau","keywords":"Acute megakaryoblastic leukemia; Cancer research; Leukemia; Cytarabine; Haematopoiesis; Biology; Immunology; Myeloid leukemia; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002738314,0.000332717,0.0004874207,0.000441547,0.0002083914,0.00005798014,0.0001114063,0.0001650188,0.00004928201],"category_scores_gemma":[0.0003163373,0.0002971167,0.00008967759,0.001495757,0.0001294952,0.0003809436,0.0002361873,0.0004646629,0.0005981458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003163753,"about_ca_system_score_gemma":0.0003596291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000626734,"about_ca_topic_score_gemma":0.00001572785,"domain_scores_codex":[0.9973838,0.00007043839,0.0003602694,0.0007524292,0.0006903024,0.0007427378],"domain_scores_gemma":[0.9984875,0.0003553924,0.00009404896,0.0003456816,0.0002187077,0.0004986619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002116469,0.0004491208,0.02766768,0.001498032,0.001024037,0.005829252,0.005007748,0.0001238182,0.43876,0.0002596561,0.4806761,0.03658805],"study_design_scores_gemma":[0.02977345,0.007969683,0.07024281,0.001259819,0.004492879,0.002735399,0.005104532,0.003037478,0.6737798,0.001397909,0.1966126,0.003593708],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925423,0.001050724,0.000198344,0.00314064,0.0002048044,0.0009288715,0.0003003306,0.0003452021,0.001288809],"genre_scores_gemma":[0.9781891,0.007134077,0.00170978,0.002400427,0.001181121,0.0001831307,0.0003070601,0.000111026,0.008784318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2840635,"threshold_uncertainty_score":0.9999481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008774708589116527,"score_gpt":0.2881528674700445,"score_spread":0.2793781588809279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}