{"id":"W4386881796","doi":"10.1182/bloodadvances.2022008899","title":"CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216","year":2023,"lang":"en","type":"article","venue":"Blood Advances","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Institute for Research in Immunology and Cancer; McGill University; Centre hospitalier universitaire de Québec; Université Laval; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; CHU Sainte-Justine Foundation; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Leukemia and Lymphoma Society; Child Health Research Foundation; Merck Canada; Cancer Research Society; Fondation Charles-Bruneau","keywords":"Acute megakaryoblastic leukemia; Cancer research; Leukemia; Cytarabine; Haematopoiesis; Biology; Immunology; Myeloid leukemia; Stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081977,0.0003306463,0.0003940336,0.000174746,0.0001293614,0.0003331825,0.0001916768,0.0002260875,0.001284742],"category_scores_gemma":[0.00008403922,0.0001101703,0.0002311547,0.0002111064,0.000164775,0.0001337298,0.0001587099,0.0005564905,0.0003426044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000339678,"about_ca_system_score_gemma":0.0002495635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408835,"about_ca_topic_score_gemma":0.002073729,"domain_scores_codex":[0.9998958,0.00001375062,0.00001076255,0.00001888495,0.00003116825,0.00002968134],"domain_scores_gemma":[0.9999239,0.000009732341,0.00001920989,0.000009215591,0.000005405479,0.00003259778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004903859,0.0001167028,0.0006801003,0.00002661717,0.00001455575,0.0001739671,0.00001981724,0.0001927654,0.9960259,0.0000982439,0.0002003268,0.001960502],"study_design_scores_gemma":[0.0001616737,0.002757273,0.02043446,0.00001151806,0.00005172229,0.001819107,0.0000783244,0.002913572,0.9657562,0.00006730058,0.005937842,0.00001102934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970297,0.0007042542,0.0004959704,0.00006350731,0.00001991265,0.00002291603,0.0006931821,0.00007126243,0.0008993128],"genre_scores_gemma":[0.9965275,0.0004187033,0.0004250232,0.00004034083,0.000005258915,0.00003665984,0.001389572,0.00002347855,0.001133563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001408835,"threshold_uncertainty_score":0.004297912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008774708589116527,"score_gpt":0.2881528674700445,"score_spread":0.2793781588809279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}