{"id":"W4386884084","doi":"10.1073/pnas.2307999120","title":"HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Environmental Health Sciences; Genentech; National Cancer Institute; National Institutes of Health; University of Hong Kong; York University; Andrew and Jaime Sullivan Family Foundation; University of Hawaiʻi Foundation; University of Hawai'i; U.S. Department of Defense","keywords":"Mesothelioma; Mesothelial Cell; HMGB1; Mesothelium; Inflammation; Asbestos; Cancer research; Secretion; Cytoplasm; Extracellular; Biology; Cell biology; Chemistry; Pathology; Immunology; Medicine; Materials science; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474911,0.0003455222,0.0003373149,0.0004370406,0.0002256589,0.0003524529,0.0002074214,0.0004957103,0.001782809],"category_scores_gemma":[0.0001287206,0.000317835,0.0003913075,0.0002073656,0.0004500141,0.0002542163,0.0004504678,0.001168347,0.0005465736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002773463,"about_ca_system_score_gemma":0.0002261959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007064937,"about_ca_topic_score_gemma":0.001131776,"domain_scores_codex":[0.9997221,0.00002607045,0.00003555967,0.00007405943,0.00006758389,0.00007469492],"domain_scores_gemma":[0.9996209,0.00002348061,0.0001300928,0.00003292914,0.00002265173,0.0001699269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009754514,0.00002380902,0.0007036069,0.00003208945,0.000005154265,0.0001015473,0.00002224197,0.00003246889,0.9985629,0.00006845391,0.0000332018,0.0003170316],"study_design_scores_gemma":[0.00002397924,0.0003392661,0.02182945,0.00001709682,0.00003505665,0.0005963431,0.0001668049,0.0007930114,0.973227,0.0001266202,0.002834946,0.00001048298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949767,0.001293749,0.00196838,0.0001708984,0.00004575441,0.00003117886,0.0006349905,0.0001420449,0.0007362303],"genre_scores_gemma":[0.9942782,0.0007393672,0.0009957023,0.00007157576,0.00001361137,0.00004007764,0.0004408829,0.00002583208,0.003394744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001782809,"threshold_uncertainty_score":0.0059641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04056683851811291,"score_gpt":0.3085821658341624,"score_spread":0.2680153273160495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}