{"id":"W4386884084","doi":"10.1073/pnas.2307999120","title":"HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Environmental Health Sciences; Genentech; National Cancer Institute; National Institutes of Health; University of Hong Kong; York University; Andrew and Jaime Sullivan Family Foundation; University of Hawaiʻi Foundation; University of Hawai'i; U.S. Department of Defense","keywords":"Mesothelioma; Mesothelial Cell; HMGB1; Mesothelium; Inflammation; Asbestos; Cancer research; Secretion; Cytoplasm; Extracellular; Biology; Cell biology; Chemistry; Pathology; Immunology; Medicine; Materials science; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006715669,0.00009118232,0.0001513022,0.0001242013,0.0001881197,0.000006811745,0.000418416,0.00005099277,0.00003784878],"category_scores_gemma":[0.0001850734,0.00004907547,0.00008702875,0.000709969,0.0006094358,0.0001305949,0.0001089492,0.00008670241,0.00001007127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000330011,"about_ca_system_score_gemma":0.00007822779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003715568,"about_ca_topic_score_gemma":4.443659e-8,"domain_scores_codex":[0.9978743,0.000005821102,0.000358262,0.0001794407,0.001451412,0.0001307324],"domain_scores_gemma":[0.9994157,0.0001242342,0.0003133514,0.00001087034,0.00009066337,0.00004520898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005548268,0.000102505,0.01730369,0.00007706897,0.00003330442,7.302851e-9,0.0003205411,0.00001857339,0.9770157,0.001145978,0.003403757,0.0005234052],"study_design_scores_gemma":[0.0001887057,0.00004426858,0.3512686,0.00007790044,0.0000210701,0.000001211662,0.0002572004,0.0001357188,0.6452962,0.002192193,0.0004731875,0.00004372159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942805,0.00007407436,3.013197e-7,0.003100771,0.00001831767,0.0002153862,0.00003794614,0.0000137244,0.002259],"genre_scores_gemma":[0.9986393,0.00002417409,0.0005345624,0.0002334927,0.00004326051,0.00001440768,0.000001184032,0.000005198454,0.0005044164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3339649,"threshold_uncertainty_score":0.2245492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04056683851811291,"score_gpt":0.3085821658341624,"score_spread":0.2680153273160495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}