{"id":"W4386884687","doi":"10.1007/s13555-023-01002-1","title":"Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study","year":2023,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"Boehringer Ingelheim","keywords":"Medicine; Placebo; Clinical endpoint; Tolerability; Adverse effect; Palmoplantar pustulosis; Internal medicine; Dosing; Confidence interval; Randomized controlled trial; Gastroenterology; Psoriasis; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00027931,0.0004103677,0.0009704948,0.0004070826,0.0004094502,0.00003385247,0.0001394824,0.0002795535,0.00006060053],"category_scores_gemma":[0.00001887943,0.000295958,0.0000630286,0.0003167482,0.0001057117,0.0001179052,0.00005903691,0.0002273211,0.0001027141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002135797,"about_ca_system_score_gemma":0.00003563237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004034152,"about_ca_topic_score_gemma":0.00009396478,"domain_scores_codex":[0.9977869,0.0005111403,0.0004725208,0.00058497,0.00006053607,0.0005838958],"domain_scores_gemma":[0.9990289,0.0004663755,0.0001372201,0.0002497739,0.00004419999,0.00007356958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7897075,0.002186983,0.1918893,0.00001366904,0.001518213,0.0001589794,0.004123241,0.00003004279,0.0002389524,0.0000302086,0.00006271304,0.01004017],"study_design_scores_gemma":[0.8992212,0.0007524099,0.09760282,0.0000373981,0.0002263506,0.00009403713,0.0007419551,0.00003466223,0.0006470351,0.00001387735,0.000272876,0.0003553737],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926296,0.001885108,0.00000692845,0.0001726037,0.0002376317,0.004809033,0.0000495032,0.00009939772,0.0001102335],"genre_scores_gemma":[0.9979586,0.0009709055,0.00001538802,0.0001420559,0.00001481743,0.000500048,0.0002454929,0.00003040008,0.0001222913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1095137,"threshold_uncertainty_score":0.9999493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02289239800228332,"score_gpt":0.2747969021528684,"score_spread":0.2519045041505851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}