{"id":"W4386884687","doi":"10.1007/s13555-023-01002-1","title":"Spesolimab Efficacy and Safety in Patients with Moderate-to-Severe Palmoplantar Pustulosis: A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase IIb, Dose-Finding Study","year":2023,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"Boehringer Ingelheim","keywords":"Medicine; Placebo; Clinical endpoint; Tolerability; Adverse effect; Palmoplantar pustulosis; Internal medicine; Dosing; Confidence interval; Randomized controlled trial; Gastroenterology; Psoriasis; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00333986,0.00134322,0.003057904,0.0003855345,0.0003134105,0.0008404908,0.0007216154,0.001741852,0.003296163],"category_scores_gemma":[0.001856834,0.0006349803,0.002571159,0.0004218613,0.0006953407,0.0008527982,0.0003041934,0.001831592,0.0007735205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004147512,"about_ca_system_score_gemma":0.000701018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002314188,"about_ca_topic_score_gemma":0.0004556743,"domain_scores_codex":[0.9988312,0.0006801391,0.0001241821,0.0001244732,0.000122441,0.0001175715],"domain_scores_gemma":[0.9989249,0.0002826848,0.0003064079,0.00009034745,0.0001030888,0.0002925461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8723629,0.01327958,0.003653274,0.001780994,0.002363115,0.0002559643,0.0001828072,0.001086999,0.034324,0.0001436785,0.001352112,0.06921453],"study_design_scores_gemma":[0.6729358,0.3121428,0.009993115,0.00005497875,0.0008299933,0.0002896244,0.00003133198,0.0007221354,0.00140928,0.0001272408,0.001434912,0.00002877357],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853389,0.009574124,0.0008567465,0.0004820256,0.0001688098,0.001703855,0.0004243094,0.00009323849,0.00135803],"genre_scores_gemma":[0.9926777,0.002419242,0.00110165,0.0009222145,0.0003047647,0.0009217982,0.0006744647,0.0000125506,0.0009656134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00333986,"threshold_uncertainty_score":0.01766306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02289239800228332,"score_gpt":0.2747969021528684,"score_spread":0.2519045041505851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}