{"id":"W4386886878","doi":"10.1016/j.ymthe.2023.09.012","title":"Optimal delivery of RNA interference by viral vectors for cancer therapy","year":2023,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Ottawa Hospital Foundation; Terry Fox Research Institute; Lotte and John Hecht Memorial Foundation","keywords":"RNA interference; Virology; Viral vector; RNA; Cancer; Cancer therapy; Biology; Genetic enhancement; Computational biology; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006662062,0.001037699,0.00121924,0.001468647,0.0001959142,0.00103064,0.0009909925,0.0009463333,0.001601753],"category_scores_gemma":[0.0004417506,0.0003960533,0.0004202484,0.00150406,0.0006176976,0.0008994126,0.0005961682,0.001879891,0.001573742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00102084,"about_ca_system_score_gemma":0.0006335416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009120873,"about_ca_topic_score_gemma":0.001300209,"domain_scores_codex":[0.9997829,0.00003277397,0.00002018306,0.00003225459,0.0001041155,0.00002777986],"domain_scores_gemma":[0.9998932,0.0000470752,0.00001924048,0.000005033139,0.00002706221,0.000008407069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001424576,0.0001354955,0.00009429983,0.01087087,0.00008257342,0.0002215483,0.00005487686,0.00149442,0.03301992,0.01541118,0.01932801,0.9191444],"study_design_scores_gemma":[0.00004574787,0.0001572738,0.0004341377,0.001533104,0.0000959551,0.0008379578,0.00002818794,0.0005527382,0.01427404,0.004197817,0.9778059,0.0000371846],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002457016,0.9971117,0.001089828,0.0001166651,0.0001752888,0.00000867709,0.00001671907,0.00001639724,0.001219034],"genre_scores_gemma":[0.001677462,0.9960526,0.001025905,0.000112078,0.00009864113,0.00001434683,0.00003989451,0.000004812313,0.0009742231],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001601753,"threshold_uncertainty_score":0.007406712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0629177868609854,"score_gpt":0.3828438029759407,"score_spread":0.3199260161149553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}