{"id":"W4386886967","doi":"10.1016/j.leukres.2023.107390","title":"Phase 1 study of JNJ-64619178, a protein arginine methyltransferase 5 inhibitor, in patients with lower-risk myelodysplastic syndromes","year":2023,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Janssen Pharmaceuticals; Janssen Research and Development","keywords":"Myelodysplastic syndromes; Methyltransferase; Arginine; Medicine; Internal medicine; Oncology; Chemistry; Methylation; Biochemistry; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008633235,0.0001832698,0.000248885,0.0004774076,0.00009349611,0.0000207715,0.0002292164,0.0001744674,0.00002337863],"category_scores_gemma":[0.0002649257,0.0001631029,0.00004603736,0.001448727,0.0001377492,0.000009779663,0.0001285028,0.0004223952,0.00002180373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021929,"about_ca_system_score_gemma":0.0005149109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004038766,"about_ca_topic_score_gemma":0.00055761,"domain_scores_codex":[0.9974432,0.0003984366,0.0003243997,0.0005481601,0.0007929921,0.0004927875],"domain_scores_gemma":[0.9989251,0.00005965482,0.00007280741,0.0005188792,0.0003143674,0.0001091629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0217761,0.009008141,0.1492225,0.0004757125,0.0007890042,0.0002026341,0.002061729,0.02431896,0.7593962,0.00002631632,0.002761136,0.02996155],"study_design_scores_gemma":[0.110617,0.08015133,0.2743592,0.0007345182,0.000143743,0.000008705636,0.001854061,0.005921664,0.5223505,0.0001403586,0.00231639,0.001402572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979178,0.00007401182,0.00005159115,0.0000367388,0.00006531744,0.001732833,0.00004350782,0.00002199804,0.00005616125],"genre_scores_gemma":[0.9988757,0.00003311717,0.00004528524,0.000002113907,0.00007559266,0.0002643352,0.0001795886,0.0000460641,0.0004782152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2370457,"threshold_uncertainty_score":0.6651142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02088103535974262,"score_gpt":0.3224272566979904,"score_spread":0.3015462213382478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}