{"id":"W4386887349","doi":"10.1001/jamasurg.2023.4405","title":"Circulating DNA in Esophageal Cancer—Utility Beyond the Prognostic Application","year":2023,"lang":"en","type":"letter","venue":"JAMA Surgery","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal General Hospital","funders":"","keywords":"Medicine; Otorhinolaryngology; Family medicine; Neurology; General surgery; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005576626,0.0002715104,0.0003250414,0.00009390094,0.00009674746,0.00008786651,0.0002783469,0.0007142795,0.0000158913],"category_scores_gemma":[0.0006729821,0.000242874,0.0002128422,0.0002563774,0.00009121327,0.000003176004,0.0001798124,0.0006891194,0.00002361472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007305061,"about_ca_system_score_gemma":0.0004158302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006855407,"about_ca_topic_score_gemma":0.0004548608,"domain_scores_codex":[0.9981469,0.00011606,0.0004463682,0.0006184436,0.0002235297,0.0004487231],"domain_scores_gemma":[0.9982141,0.0007485128,0.0002486145,0.0006597583,0.00008792492,0.00004109233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001474472,0.00001779534,0.05050842,0.000141687,0.00005130416,0.0001300779,0.00002588775,0.0000785531,0.001119146,0.000005335167,0.9346485,0.0132586],"study_design_scores_gemma":[0.0002003901,0.0000174698,0.09915902,0.00009949039,0.00006402838,0.00001943512,0.00001939655,0.000484088,0.001267815,0.000495863,0.8976603,0.000512735],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6594356,0.005732773,0.0002622461,0.3285749,0.002769593,0.001477753,0.0009081369,0.00007488098,0.0007640876],"genre_scores_gemma":[0.6802874,0.001620788,0.00002538252,0.2972788,0.01340442,0.001273238,0.005269649,0.0001712177,0.0006690741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0486506,"threshold_uncertainty_score":0.9904114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773214638578952,"score_gpt":0.2530914386451018,"score_spread":0.2353592922593122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}