{"id":"W4386895156","doi":"10.3390/cancers15184639","title":"Association between AHR Expression and Immune Dysregulation in Pancreatic Ductal Adenocarcinoma: Insights from Comprehensive Immune Profiling of Peripheral Blood Mononuclear Cells","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Immune dysregulation; Peripheral blood mononuclear cell; Immune system; Pancreatic ductal adenocarcinoma; Medicine; Gene expression profiling; Peripheral blood; Immunology; Pathology; Biology; Pancreatic cancer; Internal medicine; Gene expression; Gene; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705565,0.0001097772,0.000282218,0.0004699297,0.0001415333,0.000291362,0.00007718563,0.0001764352,0.0006256382],"category_scores_gemma":[0.0001918964,0.00007700146,0.0001322916,0.0005209958,0.0001062296,0.00008514872,0.0002025243,0.0002167039,0.0001395776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008321426,"about_ca_system_score_gemma":0.00007264227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002867174,"about_ca_topic_score_gemma":0.0004661733,"domain_scores_codex":[0.9998341,0.0000368097,0.0000136482,0.00005499356,0.00003246291,0.00002792571],"domain_scores_gemma":[0.9998852,0.00002550666,0.00003449498,0.000009150777,0.00001877883,0.00002689245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002019264,0.0001582511,0.6554654,0.0001887147,0.0001562513,0.0006345699,0.000291544,0.0001819761,0.3055347,0.00006414524,0.0002493421,0.03505591],"study_design_scores_gemma":[0.000008576519,0.0002999696,0.9890687,0.000007262731,0.00005974294,0.001062604,0.0001797808,0.0002430278,0.008058247,0.00006797101,0.0009388778,0.000005189811],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965293,0.00197993,0.0006768428,0.00002577239,0.000005107547,0.00001093839,0.0003837035,0.000009177213,0.0003793436],"genre_scores_gemma":[0.9982007,0.0005835449,0.0004745284,0.00003539162,0.00001354158,0.00001591075,0.0003891928,0.000002047949,0.0002852526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006256382,"threshold_uncertainty_score":0.002092957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.015904752668905,"score_gpt":0.2459592534882731,"score_spread":0.2300545008193681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}