{"id":"W4386898192","doi":"10.1016/j.tem.2023.08.016","title":"Disentangling the nonmetabolic roles of metabolites: lactate as a case study","year":2023,"lang":"en","type":"article","venue":"Trends in Endocrinology and Metabolism","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Computational biology; Covalent bond; Biochemistry; Chemistry; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001285085,0.0008777012,0.0006740845,0.002569017,0.001727648,0.002332337,0.001015335,0.002220846,0.002392706],"category_scores_gemma":[0.005458819,0.0004105751,0.0008256363,0.001682726,0.002024374,0.002058597,0.002320039,0.002263264,0.0004707607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001084675,"about_ca_system_score_gemma":0.00151292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00471057,"about_ca_topic_score_gemma":0.005839712,"domain_scores_codex":[0.9992354,0.0001963626,0.00009433703,0.000127258,0.000142939,0.0002036599],"domain_scores_gemma":[0.9970361,0.001549641,0.0004310641,0.0001947735,0.0002942457,0.0004941213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006044427,0.0003235354,0.09910002,0.000202776,0.00005951373,0.8612518,0.002820243,0.0003469878,0.002615555,0.004289678,0.001024512,0.02736093],"study_design_scores_gemma":[0.00004198073,0.0003036142,0.01934649,0.0003094549,0.000115531,0.9538916,0.006825833,0.001927658,0.003410262,0.005369786,0.008392156,0.00006568485],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9565181,0.01025512,0.01126137,0.008119117,0.0002475044,0.0001959834,0.0003109494,0.00006451209,0.01302725],"genre_scores_gemma":[0.9887044,0.003935101,0.004292514,0.0008741521,0.0002691491,0.00002227173,0.00009833376,0.00003938852,0.001764604],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00471057,"threshold_uncertainty_score":0.009366274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1136030790930742,"score_gpt":0.4553452717993028,"score_spread":0.3417421927062286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}