{"id":"W4386910272","doi":"10.3324/haematol.2023.282884","title":"Bone mineral density in adult patients with pyruvate kinase deficiency on long-term mitapivat treatment","year":2023,"lang":"en","type":"letter","venue":"Haematologica","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Novo Nordisk; Moderna; Swedish Orphan Biovitrum; Apellis Pharmaceuticals; Argenx; Sanofi Genzyme; Incyte; bluebird bio; Ionis Pharmaceuticals; Celgene; Sanofi; Alexion Pharmaceuticals; Amgen; Pfizer; Agios Pharmaceuticals; Bristol-Myers Squibb","keywords":"Pyruvate kinase deficiency; Pyruvate kinase; Bone mineral; Term (time); Medicine; Internal medicine; Pediatrics; Glycolysis; Metabolism; Osteoporosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005214936,0.0002414477,0.0006138436,0.0005613744,0.0006674156,0.0004422276,0.0005309522,0.004574921,0.001695836],"category_scores_gemma":[0.003406134,0.0002077652,0.0002855743,0.0009658415,0.0005859232,0.0004232214,0.0001970101,0.002323975,0.0004856306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009129525,"about_ca_system_score_gemma":0.0006073259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004959717,"about_ca_topic_score_gemma":0.006930383,"domain_scores_codex":[0.9995778,0.0001503657,0.00006096466,0.0000418791,0.00009609893,0.00007289086],"domain_scores_gemma":[0.9987898,0.0006779819,0.0001517259,0.00004359662,0.0001257815,0.0002111929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.002817982,0.0002404035,0.2668828,0.0004699656,0.0001797566,0.4687234,0.0005666854,0.0006137523,0.003523707,0.002893163,0.1788659,0.07422238],"study_design_scores_gemma":[0.0006128818,0.001192093,0.2694076,0.0009585363,0.0002915043,0.5997837,0.001585447,0.002148876,0.001096484,0.01068459,0.112155,0.00008344396],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2924621,0.05760822,0.001047816,0.5928703,0.006271212,0.00007471189,0.001167873,0.0001357474,0.04836208],"genre_scores_gemma":[0.894838,0.0119177,0.0006007981,0.07737807,0.009838224,0.00004509382,0.0003444236,0.00001495926,0.00502265],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.004959717,"threshold_uncertainty_score":0.009861648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0272006064339276,"score_gpt":0.2528535681545815,"score_spread":0.2256529617206539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}