{"id":"W4386910959","doi":"10.1002/prp2.1137","title":"Impact of amiodarone use on metoprolol concentrations, <scp>α‐OH</scp>‐metoprolol concentrations, metoprolol dosing and heart rate: A cross‐sectional study","year":2023,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; Fondation Institut de Cardiologie de Montréal","keywords":"Metoprolol; Amiodarone; Medicine; Antiarrhythmic agent; Bisoprolol; Pharmacokinetics; CYP2D6; Heart rate; Regimen; Pharmacology; Internal medicine; Anesthesia; Atrial fibrillation; Cardiology; Heart failure; Heart disease; Blood pressure; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001336422,0.0003108451,0.0004140109,0.0004821862,0.0004017596,0.000877268,0.0004409691,0.0006507765,0.0014153],"category_scores_gemma":[0.003259077,0.0004623913,0.0006969064,0.0006819087,0.0002552998,0.0004720955,0.0003494809,0.0006298709,0.0002542291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005213055,"about_ca_system_score_gemma":0.0005266756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01898097,"about_ca_topic_score_gemma":0.01768565,"domain_scores_codex":[0.9991466,0.0003495905,0.00006141191,0.0001861673,0.0001499903,0.0001062048],"domain_scores_gemma":[0.996915,0.000757756,0.0008667266,0.0003153755,0.0004515967,0.0006935222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002984873,0.00006193687,0.9986669,0.000006515964,0.0001808698,0.00002396105,0.0000332013,0.00001392511,0.0001646721,0.000005972642,0.00004447527,0.0004990001],"study_design_scores_gemma":[0.000009642472,0.0001676136,0.999541,0.000001931977,0.00005346515,0.00004053195,0.00002195978,0.00006986329,0.00002787572,0.00000243862,0.00006172351,0.000001980976],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984663,0.0004743299,0.0000851159,0.00004026864,0.000008886822,0.00001894863,0.0004953943,0.000005354257,0.0004053769],"genre_scores_gemma":[0.9991482,0.0001119302,0.00009443573,0.00003988719,0.00001555268,0.00001416547,0.0003721237,0.000002652325,0.0002009101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01898097,"threshold_uncertainty_score":0.03774101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2503148016846936,"score_gpt":0.5557490032381033,"score_spread":0.3054342015534097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}