{"id":"W4386911011","doi":"10.1128/mbio.00922-23","title":"Surface growth of <i>Pseudomonas aeruginosa</i> reveals a regulatory effect of 3-oxo-C <sub>12</sub> -homoserine lactone in the absence of its cognate receptor, LasR","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Government of Canada; Armand-Frappier Foundation; Canadian Institutes of Health Research; Dartmouth College; Oklahoma State University","keywords":"Quorum sensing; Pseudomonas aeruginosa; Biofilm; Microbiology; Biology; Activator (genetics); Bacteria; Cell biology; Regulator; Intracellular; Receptor; Adaptation (eye); Extracellular; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008699513,0.0001835538,0.0003785876,0.00004978808,0.00002932454,0.000006497757,0.0002394417,0.0001833927,0.000005983282],"category_scores_gemma":[0.0001616157,0.000142427,0.0001259762,0.0003384204,0.0001557051,0.000006408971,0.0001315134,0.0001025151,0.000008071022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007666247,"about_ca_system_score_gemma":0.0000388333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006162951,"about_ca_topic_score_gemma":0.0000409873,"domain_scores_codex":[0.9985948,0.0002400849,0.0004208415,0.0002847861,0.0001944916,0.0002650051],"domain_scores_gemma":[0.9991093,0.00009588609,0.000257966,0.00039138,0.0001050717,0.00004042367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002780121,0.00004222736,0.005479354,0.000262834,0.00003300369,0.000004237247,0.00009108398,0.000009639328,0.9923357,0.00006258598,0.001022089,0.0003792031],"study_design_scores_gemma":[0.0006687884,0.0004591418,0.02195261,0.0001441525,0.00001454962,0.000005582014,0.00002669683,0.000009837465,0.9762428,0.000009961217,0.0003306934,0.0001352095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986971,0.0004041891,0.00000119895,0.0001072433,0.0001670211,0.0002944601,0.00008461586,0.00001146798,0.0002327057],"genre_scores_gemma":[0.9989851,0.0006670986,0.00004794069,0.00004692362,0.00005527545,0.000004204171,0.00009848419,0.00002184622,0.00007318625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01647326,"threshold_uncertainty_score":0.5808004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00814879406622024,"score_gpt":0.2258467826631686,"score_spread":0.2176979885969484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}