{"id":"W4386911580","doi":"10.3390/biom13091426","title":"Coupled Electrostatic and Hydrophobic Destabilisation of the Gelsolin-Actin Complex Enables Facile Detection of Ovarian Cancer Biomarker Lysophosphatidic Acid","year":2023,"lang":"en","type":"article","venue":"Biomolecules","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Science Foundation Ireland; Irish Centre for High-End Computing; Higher Education Authority","keywords":"Gelsolin; Lysophosphatidic acid; Chemistry; Actin; Biophysics; Actin-binding protein; Binding domain; Biochemistry; Actin cytoskeleton; Binding site; Biology; Cytoskeleton; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332902,0.0001150649,0.0002418653,0.0001200001,0.0000790603,0.000004867175,0.00004831053,0.0000772595,0.0001004108],"category_scores_gemma":[0.00009710612,0.00008277968,0.00007203422,0.000584211,0.0002662857,0.00003012961,0.00003301279,0.00006050331,0.000006444232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003950309,"about_ca_system_score_gemma":0.00009470797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005295443,"about_ca_topic_score_gemma":0.0001208513,"domain_scores_codex":[0.9991348,0.00008840856,0.0002667407,0.0001879976,0.0001591121,0.0001629738],"domain_scores_gemma":[0.9993981,0.00007641537,0.0001756095,0.0001993375,0.0001048733,0.0000456983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000277439,0.00004550012,0.001866723,0.0001788568,0.00005058033,0.000001877074,0.0002379061,0.000006902461,0.9944262,0.00004012867,0.00007710518,0.002790784],"study_design_scores_gemma":[0.001026104,0.0002400189,0.1842604,0.00005544549,0.00007349761,0.0000152164,0.0002295348,0.005559637,0.8080007,0.0001481651,0.0003165588,0.00007470063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977294,0.0005540192,0.0006763001,0.000407581,0.0001736021,0.0003364786,0.00003111247,0.00004430742,0.00004717612],"genre_scores_gemma":[0.9991887,0.0003673122,0.0001212578,0.000110363,0.00002349883,0.00003318988,0.00004143432,0.00001527978,0.00009901151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1864255,"threshold_uncertainty_score":0.3375657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03274943637497897,"score_gpt":0.2810744779595812,"score_spread":0.2483250415846022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}