{"id":"W4386917891","doi":"10.3390/v15091971","title":"The Disruption of a Nuclear Export Signal in the C-Terminus of the Herpes Simplex Virus 1 Determinant of Pathogenicity UL24 Protein Leads to a Syncytial Plaque Phenotype","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research; Armand-Frappier Foundation; Yale University","keywords":"Biology; Nuclear export signal; Cytoplasm; Herpes simplex virus; Transfection; Cell nucleus; Molecular biology; Virus; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036734,0.0004004921,0.0002102132,0.0001687235,0.0001537602,0.0002437571,0.0002384571,0.0002642515,0.001135051],"category_scores_gemma":[0.0001170875,0.0001342962,0.0002500375,0.0001136242,0.0003047987,0.0001210495,0.0002433085,0.0005831895,0.0004122487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002856595,"about_ca_system_score_gemma":0.0002456572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002578274,"about_ca_topic_score_gemma":0.0004434148,"domain_scores_codex":[0.9998826,0.00002367419,0.00001383665,0.00002181957,0.00003713793,0.00002089876],"domain_scores_gemma":[0.9998943,0.0000201783,0.00003459613,0.00001675069,0.000006835961,0.00002743409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000322412,0.00001300798,0.00004325477,0.0000141821,0.000002324162,0.00004997626,0.00000536791,0.00002116152,0.9992705,0.00007281677,0.0000143801,0.0004606796],"study_design_scores_gemma":[0.000008394647,0.0001748481,0.001139537,0.000004054847,0.000008827737,0.0003643819,0.00001081899,0.0002791828,0.9956773,0.00003609565,0.002293364,0.000003285053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932138,0.00099508,0.004175614,0.00007657894,0.00004999424,0.0000570372,0.000280302,0.0001001365,0.001051518],"genre_scores_gemma":[0.9909586,0.0006744689,0.00456553,0.00002893054,0.00001017665,0.00006384783,0.0005863213,0.00003091699,0.00308117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135051,"threshold_uncertainty_score":0.003797114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03256385380210267,"score_gpt":0.3108189444615684,"score_spread":0.2782550906594657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}