{"id":"W4386924200","doi":"10.1172/jci.insight.167960","title":"Features and protective efficacy of human mAbs targeting Mycobacterium tuberculosis arabinomannan","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Epitope; Mycobacterium tuberculosis; Lipoarabinomannan; Monoclonal antibody; Polyclonal antibodies; Tuberculosis; Antibody; Immunoglobulin G; Virology; Immunology; Chemistry; Biology; Microbiology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207816,0.0003200455,0.0000943886,0.00015472,0.00005679211,0.0001538909,0.0001308791,0.000202416,0.0008594164],"category_scores_gemma":[0.0001658045,0.0000691988,0.0001175378,0.00007702849,0.0000791588,0.00008820774,0.00007523314,0.0002321083,0.0002494022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001807082,"about_ca_system_score_gemma":0.00008503131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005078735,"about_ca_topic_score_gemma":0.0002372807,"domain_scores_codex":[0.999915,0.00002134188,0.000004768512,0.00001510668,0.00001663606,0.00002704758],"domain_scores_gemma":[0.9999506,0.00001618414,0.000008766833,0.000004842853,0.000007820528,0.00001158388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000255797,0.000060247,0.0006451986,0.0000415176,0.000009566548,0.00006119506,0.00001576438,0.0001780007,0.9946685,0.00007431513,0.00006750756,0.003922286],"study_design_scores_gemma":[0.00005648395,0.002139917,0.01691444,0.00001376805,0.000068589,0.0009904478,0.00002572613,0.002049888,0.97208,0.0001183136,0.005535546,0.000006990262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99505,0.00230207,0.001077582,0.00004364231,0.00001071275,0.00002093306,0.0001206816,0.00003341548,0.001340997],"genre_scores_gemma":[0.9979355,0.0005347432,0.0004542934,0.00005479845,0.00001022636,0.00001333615,0.0003520402,0.00000512627,0.0006399086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008594164,"threshold_uncertainty_score":0.00287503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02641767361186825,"score_gpt":0.3149128195460104,"score_spread":0.2884951459341422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}