{"id":"W4386924200","doi":"10.1172/jci.insight.167960","title":"Features and protective efficacy of human mAbs targeting Mycobacterium tuberculosis arabinomannan","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Epitope; Mycobacterium tuberculosis; Lipoarabinomannan; Monoclonal antibody; Polyclonal antibodies; Tuberculosis; Antibody; Immunoglobulin G; Virology; Immunology; Chemistry; Biology; Microbiology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001681322,0.0001437993,0.0002991103,0.0002068326,0.0001582675,0.00001818398,0.00007065613,0.00009240192,0.0001041745],"category_scores_gemma":[0.0001265086,0.0001046432,0.00009724325,0.0003570622,0.000146569,0.00005909203,0.0001330821,0.0002691078,0.00005107404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000231829,"about_ca_system_score_gemma":0.00003381421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002355216,"about_ca_topic_score_gemma":0.00001134946,"domain_scores_codex":[0.998859,0.00005495118,0.000224695,0.0002651719,0.0003126286,0.0002835112],"domain_scores_gemma":[0.9994218,0.0001035263,0.00005829204,0.0001619923,0.0001186711,0.0001357199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008699142,0.0003304051,0.03853936,0.001179482,0.0003171708,0.0002539319,0.003975214,0.00000194151,0.9263933,0.00211329,0.01667468,0.009351261],"study_design_scores_gemma":[0.0008553286,0.0005944715,0.9026467,0.0001723777,0.00003698009,0.00003973355,0.0001516644,0.0000317044,0.08479597,0.0002778711,0.01025517,0.0001420891],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870158,0.0005523312,0.000001243213,0.001899815,0.00007092649,0.0004636935,0.00001529635,0.00007237975,0.009908473],"genre_scores_gemma":[0.9950244,0.0001618724,0.00008789302,0.00009988268,0.0002615153,0.00003237151,0.00007647635,0.00002114988,0.004234451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8641073,"threshold_uncertainty_score":0.4267228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02641767361186825,"score_gpt":0.3149128195460104,"score_spread":0.2884951459341422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}