{"id":"W4386927668","doi":"10.26434/chemrxiv-2023-sgcct","title":"Antibacterial marinopyrroles and pseudilins act as protonophores","year":2023,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Deutsche Forschungsgemeinschaft; Deutsches Zentrum für Infektionsforschung","keywords":"Protonophore; Antibacterial activity; Peptidoglycan; Biology; Bacteria; Biophysics; Biochemistry; Membrane; Cytoplasm; Teichoic acid; Bacterial cell structure; Depolarization; Staphylococcus aureus; Chemistry; Cell membrane; Mechanism of action; Chemiosmosis; Cell wall; ATP synthase; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147819,0.0002704333,0.0001192991,0.00009316405,0.00009018704,0.0002532759,0.0001282162,0.0003614327,0.001141829],"category_scores_gemma":[0.0001090655,0.0001112177,0.0001794342,0.00006194473,0.0002206286,0.0003159317,0.0002475541,0.0002588224,0.0003303618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001476425,"about_ca_system_score_gemma":0.00008857693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001521521,"about_ca_topic_score_gemma":0.0001766513,"domain_scores_codex":[0.9999057,0.00002073205,0.000004335938,0.00002191849,0.00002837976,0.0000189169],"domain_scores_gemma":[0.9999242,0.00001717578,0.00002608184,0.00000760632,0.000008278312,0.00001672257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007101637,0.000007931335,0.0001832743,0.00003812327,0.000003214411,0.00006942482,0.000009789241,0.0001042763,0.9978136,0.0003089639,0.0000204832,0.001369913],"study_design_scores_gemma":[0.0000260229,0.0003854956,0.004897095,0.000004288419,0.000005917228,0.0004497471,0.00002949433,0.0009407534,0.9895948,0.0002022303,0.003459193,0.000004909954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845299,0.002978251,0.00612345,0.000184612,0.00003045989,0.00004285426,0.000146255,0.00006571109,0.005898475],"genre_scores_gemma":[0.9929645,0.0008150278,0.003340392,0.00007740747,0.00001014302,0.00001847595,0.00007871342,0.000008798263,0.002686413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141829,"threshold_uncertainty_score":0.003819764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091033872477694,"score_gpt":0.2530831029281442,"score_spread":0.2321727642033673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}