{"id":"W4386932507","doi":"10.1039/d3bm01115a","title":"Delivery of siRNA using cationic rosette nanotubes for gene silencing","year":2023,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; National Institute for Nanotechnology; University of Alberta","funders":"National Research Council Canada; University of Alberta; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Gene silencing; Cationic polymerization; Small interfering RNA; RNA interference; Rosette (schizont appearance); Chemistry; Cell biology; Gene; RNA; Biology; Biochemistry; Polymer chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004546408,0.00008625281,0.0001099154,0.0001071016,0.0001536363,0.0000446305,0.0003095375,0.00005312893,0.000006704953],"category_scores_gemma":[0.00008142038,0.00008024515,0.00004973817,0.0002764921,0.0002128796,0.00001377913,0.0001377541,0.000005307079,0.00001124263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001620446,"about_ca_system_score_gemma":0.0002265521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006478556,"about_ca_topic_score_gemma":0.000005105293,"domain_scores_codex":[0.9990837,0.00001604928,0.0002154368,0.0002975359,0.000135763,0.000251498],"domain_scores_gemma":[0.9994195,0.000009448817,0.00009668574,0.0002407622,0.0001928333,0.000040837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002232689,0.000007821425,0.0001434696,0.00001845156,0.000006135678,4.407478e-7,0.00004284338,0.000143593,0.999191,0.00001135518,0.0001521658,0.0002603711],"study_design_scores_gemma":[0.0001194852,0.0001199311,0.001294502,0.00001887269,0.000007522294,0.000005217421,0.0000490426,0.0007428226,0.9973782,0.00004641492,0.0001154982,0.0001024884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984939,0.0001086306,0.0005249862,0.00002070213,0.0006025739,0.0001387779,0.00007815018,0.00001607353,0.00001627882],"genre_scores_gemma":[0.998346,0.0000763682,0.00127945,0.00004627339,0.0001354842,0.00001322003,0.00004283282,0.000008695596,0.0000517094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001812823,"threshold_uncertainty_score":0.3272302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03758099256562356,"score_gpt":0.3076218403196599,"score_spread":0.2700408477540364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}