{"id":"W4386932507","doi":"10.1039/d3bm01115a","title":"Delivery of siRNA using cationic rosette nanotubes for gene silencing","year":2023,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; National Institute for Nanotechnology; University of Alberta","funders":"National Research Council Canada; University of Alberta; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Gene silencing; Cationic polymerization; Small interfering RNA; RNA interference; Rosette (schizont appearance); Chemistry; Cell biology; Gene; RNA; Biology; Biochemistry; Polymer chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002133557,0.0002701611,0.0001953647,0.000129046,0.0001544097,0.0002379954,0.0002179778,0.000528721,0.0005799673],"category_scores_gemma":[0.0001541899,0.0001468446,0.0002017442,0.0001045757,0.0001667348,0.0001619243,0.0001764352,0.0003450071,0.0003380298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002925101,"about_ca_system_score_gemma":0.0001902308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000461687,"about_ca_topic_score_gemma":0.0009763318,"domain_scores_codex":[0.9998569,0.00002648447,0.00001429921,0.00003612321,0.00004254155,0.00002352096],"domain_scores_gemma":[0.9999028,0.00002851582,0.00002499239,0.00001144916,0.0000207144,0.00001138138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009575154,0.000003233685,0.00001266557,0.00001376516,0.000001710771,0.000009476803,0.000005939471,0.00002741833,0.9995579,0.00005148895,0.00001564077,0.0002912436],"study_design_scores_gemma":[0.000002924153,0.000036538,0.0001894306,0.000001670613,0.00000348099,0.00003649951,0.000002924658,0.0004915431,0.9983159,0.000008415754,0.0009092074,0.000001508421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590142,0.001278138,0.03576993,0.0002044494,0.00007746094,0.0002186722,0.0005726556,0.0003411658,0.00252318],"genre_scores_gemma":[0.9667031,0.0008933658,0.0260011,0.00009613503,0.000008531169,0.0002023461,0.0006900816,0.00007376843,0.005331599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005799673,"threshold_uncertainty_score":0.002122343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03758099256562356,"score_gpt":0.3076218403196599,"score_spread":0.2700408477540364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}