{"id":"W4386933236","doi":"10.1101/2023.09.20.558662","title":"Structure and dynamics of a pentameric KCTD5/Cullin3/Gβγ E3 ubiquitin ligase complex","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Canada Research Chairs; Princess Margaret Cancer Centre; University Health Network; University of Toronto; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; DNA ligase; Ubiquitin; Chemistry; Stereochemistry; Ubiquitin-Protein Ligases; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001136984,0.0002426105,0.0002748401,0.0002514489,0.000592793,0.0008097054,0.0005320964,0.0003895366,0.001964807],"category_scores_gemma":[0.0001729958,0.0002630431,0.0002144996,0.0002005158,0.0003419096,0.0003847051,0.0003060881,0.0005561668,0.0003942235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001943126,"about_ca_system_score_gemma":0.0003122239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003875343,"about_ca_topic_score_gemma":0.00251709,"domain_scores_codex":[0.9998916,0.000006868081,0.000005685895,0.00004436602,0.00002769801,0.00002372813],"domain_scores_gemma":[0.999886,0.00001025432,0.00002642746,0.000008389485,0.0000106202,0.00005825095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009523822,0.0002842511,0.0102954,0.0002049806,0.0002147255,0.00147317,0.0005137267,0.02374079,0.9492733,0.003044095,0.002234891,0.007768214],"study_design_scores_gemma":[0.0003825997,0.0008515479,0.1103673,0.0001049973,0.0001940982,0.002181851,0.001025148,0.4238878,0.4383513,0.003638699,0.01878966,0.0002250338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956353,0.0006150202,0.001871678,0.0001944073,0.00001620841,0.00001098914,0.0001996542,0.0001226784,0.001333991],"genre_scores_gemma":[0.9978533,0.0001617971,0.0007895569,0.0000581108,0.000003260076,0.000006955168,0.0004287734,0.00001300236,0.000685262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003875343,"threshold_uncertainty_score":0.01409841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850788809534701,"score_gpt":0.2347784315842029,"score_spread":0.2162705434888559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}