{"id":"W4386933482","doi":"10.1101/2023.09.19.558485","title":"Immunogenicity and Efficacy of TNX-1800, A Live Virus Recombinant Poxvirus Vaccine Candidate, Against SARS-CoV-2 Challenge in Nonhuman Primates","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Immunogenicity; Virology; Neutralizing antibody; Vaccination; Biology; Antibody; Titer; Immunology; Virus; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002726151,0.000314521,0.0002009942,0.0001653175,0.0001296931,0.0002120826,0.0001398199,0.0003529011,0.001034945],"category_scores_gemma":[0.0002258488,0.00007871453,0.0001296562,0.00006935318,0.0002683019,0.0002175946,0.00008782878,0.000373886,0.0002667827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817578,"about_ca_system_score_gemma":0.0001592909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005382338,"about_ca_topic_score_gemma":0.0004018161,"domain_scores_codex":[0.9999202,0.00002130131,0.000004105169,0.00001758024,0.00002174112,0.00001507956],"domain_scores_gemma":[0.9999326,0.00001332971,0.00001391128,0.000009633279,0.00001070565,0.0000197506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001325178,0.0005258074,0.0009371639,0.00005730174,0.00001330202,0.00007826448,0.00009180506,0.0002936549,0.9919796,0.0001076126,0.00009187951,0.004498513],"study_design_scores_gemma":[0.0005641294,0.06403577,0.04050925,0.00004372817,0.0001207553,0.001618808,0.0002376169,0.004249599,0.8820171,0.0003421773,0.006241343,0.0000198229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988519,0.0002555866,0.0002263281,0.00002096128,0.000008468945,0.00002500253,0.00006361768,0.000009063015,0.0005390531],"genre_scores_gemma":[0.9977176,0.0002222769,0.0005363043,0.0000330671,0.0000129302,0.00004462196,0.0002980947,0.000005098776,0.001130073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034945,"threshold_uncertainty_score":0.003462255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04133070044677206,"score_gpt":0.3064402892652947,"score_spread":0.2651095888185226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}