{"id":"W4386935335","doi":"10.1038/s41467-023-41067-2","title":"The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Israel Science Foundation; Weizmann Institute of Science","keywords":"HDAC3; Erg; Transcription factor; Cancer research; Biology; Cell biology; ETS transcription factor family; Repressor; Myeloid leukemia; Haematopoiesis; Genetics; Gene; Histone; Stem cell; Histone deacetylase; Biochemistry; Retinal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007280176,0.0001798698,0.0001663073,0.00009528735,0.0001377334,0.0002398361,0.0001997853,0.0001391747,0.001381523],"category_scores_gemma":[0.00007178328,0.00007715935,0.0001587353,0.00008114627,0.0002186626,0.000115289,0.0001541192,0.0003042145,0.0003571722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000343718,"about_ca_system_score_gemma":0.0001774554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009263261,"about_ca_topic_score_gemma":0.002087149,"domain_scores_codex":[0.9999028,0.00001349571,0.000004772302,0.00001774039,0.00002112735,0.00004003764],"domain_scores_gemma":[0.9999536,0.000005904963,0.00001250186,0.000005455618,0.000004275512,0.00001824823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001116256,0.00001103209,0.0001659539,0.000009571517,0.000002922139,0.00001955012,0.000003837147,0.00002118257,0.999144,0.00006474514,0.00002670044,0.0004188806],"study_design_scores_gemma":[0.00001524253,0.0001221307,0.008956767,0.000002580837,0.000009995467,0.0001266393,0.00002403667,0.000707505,0.9887347,0.00003397747,0.001263725,0.000002745803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957004,0.00108765,0.001121984,0.00009923396,0.00002390195,0.000008655491,0.0001922697,0.00004602791,0.001720024],"genre_scores_gemma":[0.9980767,0.0002705697,0.0003192304,0.00002648395,0.00000307628,0.000005007077,0.0001736301,0.000009532867,0.001115818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381523,"threshold_uncertainty_score":0.004621625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02809825252561703,"score_gpt":0.3335635566117471,"score_spread":0.3054653040861301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}