{"id":"W4386944181","doi":"10.1128/mbio.01810-23","title":"Enhanced fungal specificity and <i>in vivo</i> therapeutic efficacy of a C-22-modified FK520 analog against <i>C. neoformans</i>","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Science Foundation; National Institutes of Health; National Cancer Institute; National Institute of General Medical Sciences; Canadian Institute for Advanced Research","keywords":"Antifungal; Cryptococcus neoformans; Antifungal drugs; Medicine; In vivo; Population; Pharmacology; Intensive care medicine; Biology; Microbiology; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008988995,0.0003105442,0.000153684,0.0001058104,0.0000871441,0.0001231428,0.0001849945,0.000199897,0.001305203],"category_scores_gemma":[0.00006403887,0.00005455191,0.0001328356,0.00006727233,0.0001156773,0.00009451759,0.00007080808,0.0003636934,0.0002553948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196511,"about_ca_system_score_gemma":0.0001391475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001368075,"about_ca_topic_score_gemma":0.001168326,"domain_scores_codex":[0.9999233,0.0000132055,0.000006478522,0.00001446241,0.0000143202,0.00002824889],"domain_scores_gemma":[0.9999628,0.000005342803,0.000009689285,0.000003999839,0.000005361515,0.00001283236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003539741,0.0000895608,0.00007966736,0.00003666748,0.00000611197,0.00003628518,0.000004880766,0.000205791,0.9967885,0.00004938066,0.0001155037,0.002233648],"study_design_scores_gemma":[0.00004500131,0.002042117,0.001414207,0.000005590399,0.00001719836,0.0001636895,0.000006170011,0.0008592174,0.993966,0.0000127391,0.001462915,0.000005115778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926698,0.001562798,0.001338922,0.0001101687,0.00005812043,0.00005770742,0.0004125983,0.00009009324,0.003699899],"genre_scores_gemma":[0.9970905,0.0004430234,0.0009260725,0.00006794755,0.00000841301,0.0000151481,0.0002937781,0.000008455672,0.001146677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368075,"threshold_uncertainty_score":0.004366279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0246449543223543,"score_gpt":0.284414543021869,"score_spread":0.2597695886995147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}