{"id":"W4386944793","doi":"10.1007/s00277-023-05457-2","title":"CRISPR-Cas9 system: a novel and promising era of genotherapy for beta-hemoglobinopathies, hematological malignancy, and hemophilia","year":2023,"lang":"en","type":"review","venue":"Annals of Hematology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"CRISPR; Chimeric antigen receptor; Genome editing; Cas9; Genetic enhancement; Hematology; Leukemia; Medicine; Immunotherapy; Cancer; Computational biology; Cancer research; Immunology; Bioinformatics; Biology; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000331777,0.0004246409,0.002202162,0.000117546,0.00005138827,0.00001042792,0.0002120371,0.0006497135,0.000001209333],"category_scores_gemma":[0.0001092156,0.0003612575,0.0003465635,0.0001240616,0.000197137,0.000002866402,0.0001753606,0.0001540476,6.875084e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003330416,"about_ca_system_score_gemma":0.0001034501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007495696,"about_ca_topic_score_gemma":0.00000422804,"domain_scores_codex":[0.9978871,0.00006104095,0.000966106,0.0006011443,0.0001030826,0.0003815362],"domain_scores_gemma":[0.998772,0.0001312349,0.000478684,0.0004060671,0.000117689,0.00009436801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003674003,0.0005273538,0.000193252,0.6063131,0.00385698,0.0001072786,0.0003841831,0.00001458592,0.0412223,0.02161752,0.002650343,0.3227457],"study_design_scores_gemma":[0.003878867,0.003670453,0.00006798438,0.05794669,0.002402017,0.01197405,0.0004398378,0.0001805607,0.3258898,0.0006516876,0.5897064,0.003191694],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005949741,0.9901607,0.002416361,0.00007547258,0.0001159519,0.001007368,0.0002251913,0.00002367275,0.00002555463],"genre_scores_gemma":[0.009911323,0.9874318,0.002175821,0.00003336125,0.00007391426,0.0001670251,0.00009883134,0.00007843587,0.0000294852],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.587056,"threshold_uncertainty_score":0.9998839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08393311741432646,"score_gpt":0.3954667325821671,"score_spread":0.3115336151678406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}