{"id":"W4386944793","doi":"10.1007/s00277-023-05457-2","title":"CRISPR-Cas9 system: a novel and promising era of genotherapy for beta-hemoglobinopathies, hematological malignancy, and hemophilia","year":2023,"lang":"en","type":"review","venue":"Annals of Hematology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"CRISPR; Chimeric antigen receptor; Genome editing; Cas9; Genetic enhancement; Hematology; Leukemia; Medicine; Immunotherapy; Cancer; Computational biology; Cancer research; Immunology; Bioinformatics; Biology; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005383449,0.0007361675,0.001057727,0.001478432,0.0002018434,0.0008443584,0.0009217673,0.001112599,0.002882947],"category_scores_gemma":[0.0006137216,0.0001773571,0.0005033152,0.001072501,0.0003892022,0.0007927635,0.0005386804,0.002297267,0.001249942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005743798,"about_ca_system_score_gemma":0.0009498807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000906589,"about_ca_topic_score_gemma":0.00165116,"domain_scores_codex":[0.9998115,0.00003005295,0.00002015777,0.00003342153,0.00008132548,0.00002370927],"domain_scores_gemma":[0.9997602,0.0001123819,0.00002697084,0.00000727788,0.00006129364,0.00003192836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001067527,0.00007896469,0.0001272896,0.006467967,0.0000858325,0.0001796626,0.00002189558,0.0002732287,0.004505458,0.003755743,0.04910353,0.9352936],"study_design_scores_gemma":[0.00004626412,0.0001385734,0.0005599617,0.001037801,0.0001551511,0.001166248,0.00002445315,0.0002041136,0.002142048,0.002066102,0.992432,0.00002732359],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001823166,0.9966938,0.0007160443,0.0005880288,0.0005299969,0.000007243763,0.00004657006,0.00004175895,0.001194119],"genre_scores_gemma":[0.001526475,0.9952755,0.0007859495,0.0006729224,0.0003241286,0.00001026815,0.0001060986,0.000005928599,0.001292675],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002882947,"threshold_uncertainty_score":0.009644449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08393311741432646,"score_gpt":0.3954667325821671,"score_spread":0.3115336151678406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}