{"id":"W4386945070","doi":"10.1007/s40265-023-01934-0","title":"Treatment of Ovarian Cancer Beyond PARP Inhibition: Current and Future Options","year":2023,"lang":"en","type":"review","venue":"Drugs","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Ovarian cancer; DNA repair; Drug resistance; Cancer; Cancer research; Homologous recombination; Poly ADP ribose polymerase; Tumor microenvironment; Disease; Polymerase; Biology; Internal medicine; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007839737,0.0003740756,0.001461093,0.0002530815,0.00007222479,0.00001437649,0.00004556262,0.0002235595,0.0004074386],"category_scores_gemma":[0.000003556996,0.0002828531,0.0003971203,0.0004681177,0.0001082207,0.0000399363,0.00002343298,0.0002112322,0.00006851902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004815246,"about_ca_system_score_gemma":0.000579925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004359784,"about_ca_topic_score_gemma":0.000008029385,"domain_scores_codex":[0.9984427,0.00007662724,0.000581121,0.000413524,0.0002665374,0.0002194575],"domain_scores_gemma":[0.9989626,0.00007545955,0.0003168614,0.0003943777,0.00009003292,0.0001606812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001662032,0.0001478389,0.000004292695,0.01004148,0.0003280831,0.00001667643,0.0004722332,1.345889e-7,0.000001032355,0.001271847,0.003317022,0.9843827],"study_design_scores_gemma":[0.001368694,0.0001509026,0.00001443199,0.01218951,0.001345958,0.00005880212,0.00007121022,0.000001171432,0.00001110847,0.0001610116,0.9844184,0.0002087997],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002228796,0.9944177,0.000005244336,0.001038443,0.001143835,0.001202179,0.001075477,0.00008863529,0.001006181],"genre_scores_gemma":[0.000004465086,0.9939027,0.00009802989,0.00004364776,0.003034956,0.001176458,0.0007511277,0.00007241999,0.0009161732],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.984174,"threshold_uncertainty_score":0.9999624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07922667141945612,"score_gpt":0.4102456523476324,"score_spread":0.3310189809281763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}