{"id":"W4386945070","doi":"10.1007/s40265-023-01934-0","title":"Treatment of Ovarian Cancer Beyond PARP Inhibition: Current and Future Options","year":2023,"lang":"en","type":"review","venue":"Drugs","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Ovarian cancer; DNA repair; Drug resistance; Cancer; Cancer research; Homologous recombination; Poly ADP ribose polymerase; Tumor microenvironment; Disease; Polymerase; Biology; Internal medicine; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004324546,0.0005727488,0.0009393651,0.001103945,0.0002169487,0.0007812149,0.0006767655,0.0008166856,0.004895017],"category_scores_gemma":[0.0004142348,0.0001777916,0.0004656623,0.001022094,0.0003324106,0.001194427,0.0005201143,0.002257684,0.001953684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004753117,"about_ca_system_score_gemma":0.0006285548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006686475,"about_ca_topic_score_gemma":0.001912286,"domain_scores_codex":[0.9998778,0.00002581659,0.00001383991,0.00001986188,0.00004745129,0.00001518275],"domain_scores_gemma":[0.9998183,0.00007932205,0.00002659661,0.000005715541,0.0000475027,0.00002263949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008587066,0.00009006681,0.00009719319,0.0115597,0.00005668364,0.0001514899,0.00004441519,0.0003818043,0.001740331,0.003386858,0.0388949,0.9435107],"study_design_scores_gemma":[0.00002615176,0.0001477179,0.000455917,0.002552194,0.00007154633,0.0009029641,0.00004036948,0.0001236522,0.0003146766,0.001949425,0.9934033,0.00001216113],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001309554,0.997795,0.0001174569,0.0005819298,0.0002206568,0.000004976504,0.00001972665,0.000009106211,0.001120198],"genre_scores_gemma":[0.0006924514,0.9978042,0.0001705327,0.000346982,0.0002060204,0.000006252467,0.00003376794,0.000001860619,0.0007378274],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004895017,"threshold_uncertainty_score":0.01637542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07922667141945612,"score_gpt":0.4102456523476324,"score_spread":0.3310189809281763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}